TY - JOUR
T1 - What is the influence of grape products on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials
AU - Ghaffar, Sadia
AU - Naqvi, Mehak Ali
AU - Fayyaz, Adeela
AU - Abid, Mohammed Kadhem
AU - Khayitov, Kakhramon Najmiddinovich
AU - Jalil, Abduladheem Turki
AU - Alsaikhan, Fahad
AU - Hammid, Ali Thaeer
AU - Al-Gazally, Moaed E.
AU - Mohammadparast, Vida
AU - Jannat, Behrooz
AU - Nouri, Mehran
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/10
Y1 - 2022/10
N2 - Objective: This systematic review and meta-analysis were aimed to determine the effects of grape products on liver enzymes in adults. Methods: Databases including PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus were searched up to February 2021. Randomized clinical trials (RCTs) investigating the effect of grape products on serum concentrations of liver enzymes were included. Data were pooled using the random-effects model and weighted mean difference (WMD) was considered as the summary effect size. Results: Eight RCTs enrolling 291 participants met the inclusion criteria for this meta-analysis. The overall effect illustrated no significant change in serum levels of alanine aminotransferase (ALT) (WMD: − 2.04; 95 % CI: − 5.50 to 1.42; P = 0.24; I2 = 72.5 %), and aspartate aminotransferase (AST) (WMD: − 1.40; 95 % CI: − 3.80 to 0.99; P = 0.25; I2 = 76.0 %) in intervention group compared with the control group. Subgroup analyses revealed that the effect of grape products on ALT (WMD: − 4.97; 95 % CI: − 8.73 to − 1.21; P = 0.01) and AST (WMD: − 2.89; 95 % CI: − 5.69 to − 0.08; P = 0.04) levels was significant when the intervention period was equal or more than 12 weeks. Conclusion: Overall, grape products had no significant effect on liver enzymes in adults. However, due to the low number of included studies, these findings must be interpreted with great caution. Larger, well-designed RCTs are still needed to further evaluate the capacity of the grape products as a complementary treatment to improve liver enzymes.
AB - Objective: This systematic review and meta-analysis were aimed to determine the effects of grape products on liver enzymes in adults. Methods: Databases including PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus were searched up to February 2021. Randomized clinical trials (RCTs) investigating the effect of grape products on serum concentrations of liver enzymes were included. Data were pooled using the random-effects model and weighted mean difference (WMD) was considered as the summary effect size. Results: Eight RCTs enrolling 291 participants met the inclusion criteria for this meta-analysis. The overall effect illustrated no significant change in serum levels of alanine aminotransferase (ALT) (WMD: − 2.04; 95 % CI: − 5.50 to 1.42; P = 0.24; I2 = 72.5 %), and aspartate aminotransferase (AST) (WMD: − 1.40; 95 % CI: − 3.80 to 0.99; P = 0.25; I2 = 76.0 %) in intervention group compared with the control group. Subgroup analyses revealed that the effect of grape products on ALT (WMD: − 4.97; 95 % CI: − 8.73 to − 1.21; P = 0.01) and AST (WMD: − 2.89; 95 % CI: − 5.69 to − 0.08; P = 0.04) levels was significant when the intervention period was equal or more than 12 weeks. Conclusion: Overall, grape products had no significant effect on liver enzymes in adults. However, due to the low number of included studies, these findings must be interpreted with great caution. Larger, well-designed RCTs are still needed to further evaluate the capacity of the grape products as a complementary treatment to improve liver enzymes.
KW - Alanine aminotransferase
KW - Aspartate aminotransferase
KW - Grape
KW - Liver function
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85131835395&partnerID=8YFLogxK
U2 - 10.1016/j.ctim.2022.102845
DO - 10.1016/j.ctim.2022.102845
M3 - Review article
C2 - 35671889
AN - SCOPUS:85131835395
SN - 0965-2299
VL - 69
JO - Complementary Therapies in Medicine
JF - Complementary Therapies in Medicine
M1 - 102845
ER -