Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

Awais Khalid; Pervaiz Ahmad; Abdulrahman I. Alharthi; Saleh Muhammad; Mayeen Uddin Khandaker; Mohammad Rashed Iqbal Faruque; Israf Ud Din; Mshari A. Alotaibi

doi:10.3390/cryst11020171

Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

Awais Khalid
, Pervaiz Ahmad
, Abdulrahman I. Alharthi
, Saleh Muhammad
, Mayeen Uddin Khandaker
, Mohammad Rashed Iqbal Faruque
, Israf Ud Din
, Mshari A. Alotaibi

Chemistry

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Highly crystalline titanium dioxide nanoparticles (TiO₂-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO₂-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO₂-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO₂-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO₂-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

Original language	English
Article number	171
Pages (from-to)	1-10
Number of pages	10
Journal	Crystals
Volume	11
Issue number	2
DOIs	https://doi.org/10.3390/cryst11020171
State	Published - Feb 2021

Keywords

Computed tomography
Highly crystalline
Nanoparticles
Titanium dioxide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cryst11020171

Cite this

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title = "Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography",

abstract = "Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.",

keywords = "Computed tomography, Highly crystalline, Nanoparticles, Titanium dioxide",

author = "Awais Khalid and Pervaiz Ahmad and Alharthi, \{Abdulrahman I.\} and Saleh Muhammad and Khandaker, \{Mayeen Uddin\} and Faruque, \{Mohammad Rashed Iqbal\} and Din, \{Israf Ud\} and Alotaibi, \{Mshari A.\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = feb,

doi = "10.3390/cryst11020171",

language = "English",

volume = "11",

pages = "1--10",

journal = "Crystals",

issn = "2073-4352",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

AU - Khalid, Awais

AU - Ahmad, Pervaiz

AU - Alharthi, Abdulrahman I.

AU - Muhammad, Saleh

AU - Khandaker, Mayeen Uddin

AU - Faruque, Mohammad Rashed Iqbal

AU - Din, Israf Ud

AU - Alotaibi, Mshari A.

PY - 2021/2

Y1 - 2021/2

N2 - Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

AB - Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

KW - Computed tomography

KW - Highly crystalline

KW - Nanoparticles

KW - Titanium dioxide

UR - https://www.scopus.com/pages/publications/85101049869

U2 - 10.3390/cryst11020171

DO - 10.3390/cryst11020171

M3 - Article

AN - SCOPUS:85101049869

SN - 2073-4352

VL - 11

SP - 1

EP - 10

JO - Crystals

JF - Crystals

IS - 2

M1 - 171

ER -

Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

Abstract

Keywords

UN SDGs

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