Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

Awais Khalid; Pervaiz Fazale Ahmad; Abdulrahman I. Alharthi; Saleh Muhammad; Mayeen Uddin Khandaker; Mohammad Rashed Iqbal Faruque; Israf Ud Din; Mshari A. Alotaibi

doi:10.3390/cryst11020171

Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

Awais Khalid, Pervaiz Fazale Ahmad, Abdulrahman I. Alharthi, Saleh Muhammad, Mayeen Uddin Khandaker, Mohammad Rashed Iqbal Faruque, Israf Ud Din, Mshari A. Alotaibi

Chemistry

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Highly crystalline titanium dioxide nanoparticles (TiO₂-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO₂-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO₂-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO₂-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO₂-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

Original language	English
Article number	171
Pages (from-to)	1-10
Number of pages	10
Journal	Crystals
Volume	11
Issue number	2
DOIs	https://doi.org/10.3390/cryst11020171
State	Published - Feb 2021

Keywords

Computed tomography
Highly crystalline
Nanoparticles
Titanium dioxide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cryst11020171

Cite this

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title = "Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography",

abstract = "Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.",

keywords = "Computed tomography, Highly crystalline, Nanoparticles, Titanium dioxide",

author = "Awais Khalid and \{Fazale Ahmad\}, Pervaiz and Alharthi, \{Abdulrahman I.\} and Saleh Muhammad and Khandaker, \{Mayeen Uddin\} and Faruque, \{Mohammad Rashed Iqbal\} and Din, \{Israf Ud\} and Alotaibi, \{Mshari A.\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = feb,

doi = "10.3390/cryst11020171",

language = "English",

volume = "11",

pages = "1--10",

journal = "Crystals",

issn = "2073-4352",

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TY - JOUR

T1 - Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

AU - Khalid, Awais

AU - Fazale Ahmad, Pervaiz

AU - Alharthi, Abdulrahman I.

AU - Muhammad, Saleh

AU - Khandaker, Mayeen Uddin

AU - Faruque, Mohammad Rashed Iqbal

AU - Din, Israf Ud

AU - Alotaibi, Mshari A.

PY - 2021/2

Y1 - 2021/2

N2 - Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

AB - Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

KW - Computed tomography

KW - Highly crystalline

KW - Nanoparticles

KW - Titanium dioxide

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U2 - 10.3390/cryst11020171

DO - 10.3390/cryst11020171

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VL - 11

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EP - 10

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JF - Crystals

IS - 2

M1 - 171

ER -

Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

Abstract

Keywords

UN SDGs

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