TY - JOUR
T1 - Unlocking the role of tRNA-derived fragments in shaping breast cancer signaling
AU - Hsu, Chou Yi
AU - Jasim, Saade Abdalkareem
AU - Jyothi, Renuka S.
AU - Ahmad, Irfan
AU - Hjazi, Ahmed
AU - Alubiady, Mahmood Hasen Shuhata
AU - Sinha, Aashna
AU - Mustafa, Yasser Fakri
AU - Al-Ani, Ahmed Muzahem
AU - Hussn, Ahmed
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
PY - 2025
Y1 - 2025
N2 - A new class of tiny non-coding RNAs (ncRNAs) known as tRNA-derived fragments (tRFs) is produced when mature tRNAs or tRNA precursors are cleaved. The discovery of more and more tRFs with essential roles in many physiological and pathological processes has been made possible by advancements in high-throughput sequencing. tRFs are considered important regulators of human disorders, particularly cancer, because they may control cell viability, differentiation, and homeostasis via various methods. Furthermore, there is growing evidence that extracellular tRFs could be used as potential biomarkers for cancer liquid biopsy diagnosis and prognosis. The biogenesis, categorization, and alteration of tRFs are the main topics of this review. We also provide an overview of the various roles that tRFs play in breast cancer (BC), focusing on the state of studies and future directions for tRFs in this field.
AB - A new class of tiny non-coding RNAs (ncRNAs) known as tRNA-derived fragments (tRFs) is produced when mature tRNAs or tRNA precursors are cleaved. The discovery of more and more tRFs with essential roles in many physiological and pathological processes has been made possible by advancements in high-throughput sequencing. tRFs are considered important regulators of human disorders, particularly cancer, because they may control cell viability, differentiation, and homeostasis via various methods. Furthermore, there is growing evidence that extracellular tRFs could be used as potential biomarkers for cancer liquid biopsy diagnosis and prognosis. The biogenesis, categorization, and alteration of tRFs are the main topics of this review. We also provide an overview of the various roles that tRFs play in breast cancer (BC), focusing on the state of studies and future directions for tRFs in this field.
KW - Apoptosis
KW - Breast cancer
KW - Cancer cell signaling
KW - Cell viability
KW - TRFs
KW - TRNA-derived fragments
UR - http://www.scopus.com/inward/record.url?scp=105011149135&partnerID=8YFLogxK
U2 - 10.1007/s00210-025-04407-1
DO - 10.1007/s00210-025-04407-1
M3 - Review article
AN - SCOPUS:105011149135
SN - 0028-1298
JO - Naunyn-Schmiedeberg's Archives of Pharmacology
JF - Naunyn-Schmiedeberg's Archives of Pharmacology
ER -
