TY - JOUR
T1 - Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease
T2 - a potential approach for therapeutic intervention
AU - Shirbhate, Ekta
AU - Pandey, Jaiprakash
AU - Patel, Vijay K.
AU - Kamal, Mehnaz
AU - Jawaid, Talha
AU - Gorain, Bapi
AU - Kesharwani, Prashant
AU - Rajak, Harish
N1 - Publisher Copyright:
© 2021, Maj Institute of Pharmacology Polish Academy of Sciences.
PY - 2021/12
Y1 - 2021/12
N2 - Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
AB - Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
KW - Acute lung injury
KW - Acute respiratory distress syndrome
KW - Angiotensin-converting enzyme-2
KW - COVID-19
KW - rhACE2
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85119229158&partnerID=8YFLogxK
U2 - 10.1007/s43440-021-00303-6
DO - 10.1007/s43440-021-00303-6
M3 - Review article
C2 - 34176080
AN - SCOPUS:85119229158
SN - 2299-5684
VL - 73
SP - 1539
EP - 1550
JO - Pharmacological Reports
JF - Pharmacological Reports
IS - 6
ER -