Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

Ekta Shirbhate, Jaiprakash Pandey, Vijay K. Patel, Mehnaz Kamal, Talha Jawaid, Bapi Gorain, Prashant Kesharwani, Harish Rajak

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.

Original languageEnglish
Pages (from-to)1539-1550
Number of pages12
JournalPharmacological Reports
Volume73
Issue number6
DOIs
StatePublished - Dec 2021

Keywords

  • Acute lung injury
  • Acute respiratory distress syndrome
  • Angiotensin-converting enzyme-2
  • COVID-19
  • rhACE2
  • SARS-CoV-2

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