Ultrasound-accelerated green synthesis of new quinolin-2-thione derivatives and antimicrobial evaluation against Escherichia coli and Staphylococcus aureus

Mohammed H. Geesi; Moustapha E. Moustapha; Mohammed A. Bakht; Yassine Riadi

doi:10.1016/j.scp.2019.100195

Ultrasound-accelerated green synthesis of new quinolin-2-thione derivatives and antimicrobial evaluation against Escherichia coli and Staphylococcus aureus

Mohammed H. Geesi, Moustapha E. Moustapha, Mohammed A. Bakht, Yassine Riadi

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13 Scopus citations

Abstract

An efficient, green strategy to access to a new series of quinolinthiones was investigated. The targeted derivatives have been prepared from arylhydrazides and 2-thiocoumarin under ultrasound irradiation in refluxing water. The remarkable features of this strategy are simple procedure, high conversion, cleaner with short reaction times. All resultant compounds were screened against bacterial strains for in vitro anti-bacterial activity. Derivative (6b) was showed highest potency with 22 and 24 mm inhibition zone against Staphylococcus aureus (Sa) and Escherichia coli (Ec), respectively.

Original language	English
Article number	100195
Journal	Sustainable Chemistry and Pharmacy
Volume	15
DOIs	https://doi.org/10.1016/j.scp.2019.100195
State	Published - Mar 2020

Keywords

4-Methyl-2-thiocoumarin
Anti-bacterial
Green
Hydrazides
Ultrasound irradiation
Water

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title = "Ultrasound-accelerated green synthesis of new quinolin-2-thione derivatives and antimicrobial evaluation against Escherichia coli and Staphylococcus aureus",

abstract = "An efficient, green strategy to access to a new series of quinolinthiones was investigated. The targeted derivatives have been prepared from arylhydrazides and 2-thiocoumarin under ultrasound irradiation in refluxing water. The remarkable features of this strategy are simple procedure, high conversion, cleaner with short reaction times. All resultant compounds were screened against bacterial strains for in vitro anti-bacterial activity. Derivative (6b) was showed highest potency with 22 and 24 mm inhibition zone against Staphylococcus aureus (Sa) and Escherichia coli (Ec), respectively.",

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language = "English",

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T1 - Ultrasound-accelerated green synthesis of new quinolin-2-thione derivatives and antimicrobial evaluation against Escherichia coli and Staphylococcus aureus

AU - Geesi, Mohammed H.

AU - Moustapha, Moustapha E.

AU - Bakht, Mohammed A.

AU - Riadi, Yassine

PY - 2020/3

Y1 - 2020/3

N2 - An efficient, green strategy to access to a new series of quinolinthiones was investigated. The targeted derivatives have been prepared from arylhydrazides and 2-thiocoumarin under ultrasound irradiation in refluxing water. The remarkable features of this strategy are simple procedure, high conversion, cleaner with short reaction times. All resultant compounds were screened against bacterial strains for in vitro anti-bacterial activity. Derivative (6b) was showed highest potency with 22 and 24 mm inhibition zone against Staphylococcus aureus (Sa) and Escherichia coli (Ec), respectively.

AB - An efficient, green strategy to access to a new series of quinolinthiones was investigated. The targeted derivatives have been prepared from arylhydrazides and 2-thiocoumarin under ultrasound irradiation in refluxing water. The remarkable features of this strategy are simple procedure, high conversion, cleaner with short reaction times. All resultant compounds were screened against bacterial strains for in vitro anti-bacterial activity. Derivative (6b) was showed highest potency with 22 and 24 mm inhibition zone against Staphylococcus aureus (Sa) and Escherichia coli (Ec), respectively.

KW - 4-Methyl-2-thiocoumarin

KW - Anti-bacterial

KW - Green

KW - Hydrazides

KW - Ultrasound irradiation

KW - Water

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DO - 10.1016/j.scp.2019.100195

M3 - Article

AN - SCOPUS:85076320193

SN - 2352-5541

VL - 15

JO - Sustainable Chemistry and Pharmacy

JF - Sustainable Chemistry and Pharmacy

M1 - 100195

ER -

Ultrasound-accelerated green synthesis of new quinolin-2-thione derivatives and antimicrobial evaluation against Escherichia coli and Staphylococcus aureus

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Keywords

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