TY - JOUR
T1 - The Use of Nanoneedles in Drug Delivery
T2 - an Overview of Recent Trends and Applications
AU - Rahamathulla, Mohamed
AU - Murugesan, Santhosh
AU - Gowda, D. V.
AU - Alamri, Ali H.
AU - Ahmed, Mohammed Muqtader
AU - Osmani, Riyaz Ali M.
AU - Ramamoorthy, Sathish
AU - Veeranna, Balamuralidhara
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
PY - 2023/12
Y1 - 2023/12
N2 - Nanoneedles (NN) are growing rapidly as a means of navigating biological membranes and delivering therapeutics intracellularly. Nanoneedle arrays (NNA) are among the most potential resources to achieve therapeutic effects by administration of drugs through the skin. Although this is based on well-established approaches, its implementations are rapidly developing as an important pharmaceutical and biological research phenomenon. This study intends to provide a broad overview of current NNA research, with an emphasis on existing approaches, applications, and types of compounds released by these systems. A nanoneedle-based delivery device with great spatial and temporal accuracy, minimal interference, and low toxicity could transfer biomolecules into living organisms. Due to its vast potential, NN has been widely used as a capable transportation system of many therapeutic active substances, from cancer therapy, vaccine delivery, cosmetics, and bio-sensing nanocarrier drugs to genes. The use of nanoneedles for drug delivery offers new opportunities for the rapid, targeted, and exact administration of biomolecules into cell membranes for high-resolution research of biological systems, and it can treat a wide range of biological challenges. As a result, the literature has analyzed existing patents to emphasize the status of NNA in biological applications. Graphical Abstract: [Figure not available: see fulltext.]
AB - Nanoneedles (NN) are growing rapidly as a means of navigating biological membranes and delivering therapeutics intracellularly. Nanoneedle arrays (NNA) are among the most potential resources to achieve therapeutic effects by administration of drugs through the skin. Although this is based on well-established approaches, its implementations are rapidly developing as an important pharmaceutical and biological research phenomenon. This study intends to provide a broad overview of current NNA research, with an emphasis on existing approaches, applications, and types of compounds released by these systems. A nanoneedle-based delivery device with great spatial and temporal accuracy, minimal interference, and low toxicity could transfer biomolecules into living organisms. Due to its vast potential, NN has been widely used as a capable transportation system of many therapeutic active substances, from cancer therapy, vaccine delivery, cosmetics, and bio-sensing nanocarrier drugs to genes. The use of nanoneedles for drug delivery offers new opportunities for the rapid, targeted, and exact administration of biomolecules into cell membranes for high-resolution research of biological systems, and it can treat a wide range of biological challenges. As a result, the literature has analyzed existing patents to emphasize the status of NNA in biological applications. Graphical Abstract: [Figure not available: see fulltext.]
KW - drug delivery strategies
KW - intracellular drug delivery
KW - nanocarrier
KW - nanoneedle
KW - therapeutic applications
UR - http://www.scopus.com/inward/record.url?scp=85174539823&partnerID=8YFLogxK
U2 - 10.1208/s12249-023-02661-1
DO - 10.1208/s12249-023-02661-1
M3 - Review article
C2 - 37857918
AN - SCOPUS:85174539823
SN - 1530-9932
VL - 24
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
IS - 8
M1 - 216
ER -
