The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals

Mansoor Khaledi; Behnam Poureslamfar; Hashem O. Alsaab; Shahrad Tafaghodi; Ahmed Hjazi; Rajesh Singh; Ahmed Hussien Alawadi; Ali Alsaalamy; Qutaiba A. Qasim; Fatemeh Sameni

doi:10.1186/s13213-023-01744-5

The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals

Mansoor Khaledi
, Behnam Poureslamfar
, Hashem O. Alsaab
, Shahrad Tafaghodi
, Ahmed Hjazi
, Rajesh Singh
, Ahmed Hussien Alawadi
, Ali Alsaalamy
, Qutaiba A. Qasim
, Fatemeh Sameni

Medical Laboratory Sciences

Shahed University
Shahrekord University of Medical Sciences
Yasouj University
Taif University
Isfahan University of Medical Sciences
Uttaranchal University
The Islamic University, Najaf
Imam Ja'afar Al-Sadiq University
Al-Ayen University

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Background: The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body: Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption. Conclusion: The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.

Original language	English
Article number	1
Journal	Annals of Microbiology
Volume	74
Issue number	1
DOIs	https://doi.org/10.1186/s13213-023-01744-5
State	Published - Dec 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger

Keywords

Aging
Gut microbiota
Inflammatory disease
Metabolism
Probiotic

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10.1186/s13213-023-01744-5

Cite this

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title = "The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals",

abstract = "Background: The gut microbiota plays a crucial role in regulating the host{\textquoteright}s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body: Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption. Conclusion: The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.",

keywords = "Aging, Gut microbiota, Inflammatory disease, Metabolism, Probiotic",

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doi = "10.1186/s13213-023-01744-5",

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T2 - a focus on elderly individuals

AU - Khaledi, Mansoor

AU - Poureslamfar, Behnam

AU - Alsaab, Hashem O.

AU - Tafaghodi, Shahrad

AU - Hjazi, Ahmed

AU - Singh, Rajesh

AU - Alawadi, Ahmed Hussien

AU - Alsaalamy, Ali

AU - Qasim, Qutaiba A.

AU - Sameni, Fatemeh

PY - 2024/12

Y1 - 2024/12

N2 - Background: The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body: Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption. Conclusion: The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.

AB - Background: The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body: Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption. Conclusion: The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.

KW - Aging

KW - Gut microbiota

KW - Inflammatory disease

KW - Metabolism

KW - Probiotic

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DO - 10.1186/s13213-023-01744-5

M3 - Review article

AN - SCOPUS:85181244113

SN - 1590-4261

VL - 74

JO - Annals of Microbiology

JF - Annals of Microbiology

IS - 1

M1 - 1

ER -

The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals

Abstract

UN SDGs

Keywords

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