TY - JOUR
T1 - The role of gut microbiota in human metabolism and inflammatory diseases
T2 - a focus on elderly individuals
AU - Khaledi, Mansoor
AU - Poureslamfar, Behnam
AU - Alsaab, Hashem O.
AU - Tafaghodi, Shahrad
AU - Hjazi, Ahmed
AU - Singh, Rajesh
AU - Alawadi, Ahmed Hussien
AU - Alsaalamy, Ali
AU - Qasim, Qutaiba A.
AU - Sameni, Fatemeh
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/12
Y1 - 2024/12
N2 - Background: The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body: Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption. Conclusion: The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.
AB - Background: The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body: Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption. Conclusion: The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.
KW - Aging
KW - Gut microbiota
KW - Inflammatory disease
KW - Metabolism
KW - Probiotic
UR - https://www.scopus.com/pages/publications/85181244113
U2 - 10.1186/s13213-023-01744-5
DO - 10.1186/s13213-023-01744-5
M3 - Review article
AN - SCOPUS:85181244113
SN - 1590-4261
VL - 74
JO - Annals of Microbiology
JF - Annals of Microbiology
IS - 1
M1 - 1
ER -
