TY - JOUR
T1 - The Role of Exosomal miRNAs in Female Infertility
T2 - Therapeutic Potential and Mechanisms of Action
AU - Abdulmonem, Waleed Al
AU - Ahsan, Marya
AU - Mallick, Ayaz Khurram
AU - Mohamed, Asma’a H.
AU - Waggiallah, Hisham Ali
AU - Shafie, Alaa
AU - Alzahrani, Hassan Swed
AU - Ashour, Amal Adnan
AU - Rab, Safia Obaidur
AU - Mirdad, Mohammed Tarek
AU - Ali, Hatim T.O.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
PY - 2025/6
Y1 - 2025/6
N2 - Reproductive disorders, including preeclampsia (PE), endometriosis, premature ovarian failure (POF), and polycystic ovary syndrome (PCOS), present substantial challenges to women’s reproductive health. Exosomes (EXOs) are cell-derived vesicles containing molecules that influence target cells’ gene expression and cellular behavior. Among their cargo, microRNAs (miRNAs)—short, non-coding RNAs typically 19–25 nucleotides in length—play a crucial role in post-transcriptional gene regulation and have been extensively studied for their therapeutic potential. miRNAs are considered therapeutic targets because they regulate key cellular pathways such as proliferation, apoptosis, angiogenesis, and tissue repair. This review examines the role of exosomal miRNAs from sources such as mesenchymal stem cells (MSCs), plasma, and amniotic fluid in female reproductive disorders, including PE, POF, PCOS, and endometriosis. We discuss their biological origins, mechanisms of miRNA sorting and packaging, and their therapeutic applications in modulating disease progression. By categorizing miRNAs according to their beneficial or detrimental effects in specific conditions, we aim to simplify the understanding of their roles in female infertility.
AB - Reproductive disorders, including preeclampsia (PE), endometriosis, premature ovarian failure (POF), and polycystic ovary syndrome (PCOS), present substantial challenges to women’s reproductive health. Exosomes (EXOs) are cell-derived vesicles containing molecules that influence target cells’ gene expression and cellular behavior. Among their cargo, microRNAs (miRNAs)—short, non-coding RNAs typically 19–25 nucleotides in length—play a crucial role in post-transcriptional gene regulation and have been extensively studied for their therapeutic potential. miRNAs are considered therapeutic targets because they regulate key cellular pathways such as proliferation, apoptosis, angiogenesis, and tissue repair. This review examines the role of exosomal miRNAs from sources such as mesenchymal stem cells (MSCs), plasma, and amniotic fluid in female reproductive disorders, including PE, POF, PCOS, and endometriosis. We discuss their biological origins, mechanisms of miRNA sorting and packaging, and their therapeutic applications in modulating disease progression. By categorizing miRNAs according to their beneficial or detrimental effects in specific conditions, we aim to simplify the understanding of their roles in female infertility.
KW - Exosome
KW - Female Infertility
KW - Mesenchymal Stem Cell
KW - MiRNA
KW - MicroRNA
KW - Reproductive Diseases
UR - http://www.scopus.com/inward/record.url?scp=105000855707&partnerID=8YFLogxK
U2 - 10.1007/s12015-025-10869-w
DO - 10.1007/s12015-025-10869-w
M3 - Article
AN - SCOPUS:105000855707
SN - 2629-3269
VL - 21
SP - 1141
EP - 1159
JO - Stem Cell Reviews and Reports
JF - Stem Cell Reviews and Reports
IS - 5
ER -
