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The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms

  • Dhiaa lattef Gossa Al-Saadde
  • , Ali Murtaza Haider
  • , Arsalan Ali
  • , Ebraheem Abdu Musad Saleh
  • , Abduladheem Turki Jalil
  • , Furqan M. Abdulelah
  • , Rosario Mireya Romero-Parra
  • , Nahla A. Tayyib
  • , Andrés Alexis Ramírez-Coronel
  • , Ameer S. Alkhayyat
  • University of Basrah
  • Faisalabad Medical University
  • Rawalpindi Medical College
  • Al-Mustaqbal University College
  • Al-Bayan University
  • Universidad Continental
  • Umm Al-Qura University
  • Universidad Católica de Cuenca
  • Universidad de Palermo Argentina
  • Universidad Nacional de Educación, Ecuador
  • Universidad CES
  • The Islamic University, Najaf

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

In the recent years, micronutrients play an important role in improving body health with preventing and treating of chronic diseases. Chromium is one of the vital minerals involved in the regulation of insulin action. According to abundant evidences this mineral seems to be an essential factor involved in the reduction of insulin resistance and decreasing the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs). Moreover, it has been proposed that Chromium supplementation affects mechanisms involved in blood pressure, lipid metabolism, inflammation, and oxidative stress. For instance, it may affect blood pressure through alteration of the renin-angiotensin system, as well as reducing the angiotensin-converting enzyme activity. Furthermore, Chromium supplementation might help reduce the coronary heart disease rates. This study aims to provide a comprehensive review regarding to the effects of Chromium supplementation on CVDs risk factors with an emphasis on possible molecular mechanisms.

Original languageEnglish
Article numbere19826
JournalHeliyon
Volume9
Issue number9
DOIs
StatePublished - Sep 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Cardiovascular diseases
  • Chromium
  • Hypertension
  • Inflammation
  • Oxidative stress

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