TY - JOUR
T1 - The evaluation of cd3, cd 5, cd10, cd 19, and cd20 markers in the differential diagnosis of the lymphoma subtypes in sudanese patients
AU - Abdelwadoud, Mohamed Elfatih
AU - Ahmed, Nabawia S.
AU - Alhaj, Hadia
AU - Waggiallah, Hisham Ali
N1 - Publisher Copyright:
© 2021, International Medical Research and Development Corporation. All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - The objective of this paper was to evaluate the use of CD3, CD5, CD10, CD19, and CD20 markers in the differential identification of lymphoma subtypes. Methods and Results: This was a retrospective cross-sectional study included 82 patients with palpable lymphadenopathies. The formalin-fixed paraffin block sections immunostained with the Dako flex were investigated. CD3, CD5, CD10, CD19, and CD20 staining was performed on sections. The current study found that the two main types of lymphoma, Hodgkin’s lymphoma, amd non-Hodgkin’s lymphoma, have a significant association with CD3, CD10, and CD19, and a highly significant association with CD20, implying that these CD markers are crucial for general classification and diagnosis of lymphoma. CD3 had a highly significant relationship with gender. CD3 and CD20 were demonstrated to have a significant relationship with the lymphoma subtypes. The CD20 marker is the most consistent and useful marker for differentiating lymphoma subtypes.(International Journal of Biomedicine. 2021;11(4):493-497.).
AB - The objective of this paper was to evaluate the use of CD3, CD5, CD10, CD19, and CD20 markers in the differential identification of lymphoma subtypes. Methods and Results: This was a retrospective cross-sectional study included 82 patients with palpable lymphadenopathies. The formalin-fixed paraffin block sections immunostained with the Dako flex were investigated. CD3, CD5, CD10, CD19, and CD20 staining was performed on sections. The current study found that the two main types of lymphoma, Hodgkin’s lymphoma, amd non-Hodgkin’s lymphoma, have a significant association with CD3, CD10, and CD19, and a highly significant association with CD20, implying that these CD markers are crucial for general classification and diagnosis of lymphoma. CD3 had a highly significant relationship with gender. CD3 and CD20 were demonstrated to have a significant relationship with the lymphoma subtypes. The CD20 marker is the most consistent and useful marker for differentiating lymphoma subtypes.(International Journal of Biomedicine. 2021;11(4):493-497.).
KW - CD markers
KW - Hodgkin’s lymphoma
KW - Immunohistochemistry
KW - Non-Hodgkin’s lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85121734508&partnerID=8YFLogxK
U2 - 10.21103/Article11(4)_OA14
DO - 10.21103/Article11(4)_OA14
M3 - Article
AN - SCOPUS:85121734508
SN - 2158-0510
VL - 11
SP - 493
EP - 497
JO - International Journal of Biomedicine
JF - International Journal of Biomedicine
IS - 4
ER -
