TY - JOUR
T1 - The Effect of Endometrial Scratch on Pregnancy Rate in Women with Previous Intrauterine Insemination Failure
T2 - a Systematic Review and Meta-analysis of Randomized Controlled Trials
AU - Baradwan, Saeed
AU - Alshahrani, Majed Saeed
AU - AlSghan, Rayan
AU - Alkhamis, Waleed H.
AU - Alsharif, Saud Abdullah
AU - Alanazi, Gharam Abdulrahman
AU - Abdelwahed, Rania Mahfouz
AU - Alkholy, Eman A.
AU - Fouad, Mahmoud
AU - Saleh, Mohamed
AU - Abdelati, Manal G.
AU - Alazazy, Hosam Eldin Mohamad
AU - Elsenity, Mohamed A.
AU - Abdelhakim, Ahmed Mohamed
AU - Mohamed, Mohamed Abdelsattar
AU - Abbas, Ahmed M.
AU - Mojahed, Eman M.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Society for Reproductive Investigation.
PY - 2023/5
Y1 - 2023/5
N2 - The objective of this study was to evaluate the impact of endometrial scratch on the pregnancy rate among women with previous failed intrauterine insemination (IUI). A systematic search was done in PubMed, Cochrane Library, Scopus, and ISI web of science from inception to November 2021. We selected randomized clinical trials (RCTs) that compared endometrial scratch in the intervention group versus placebo or no intervention in the control group among infertile women with previous failure of IUI regarding different pregnancy outcomes. Revman software was utilized for performing our meta-analysis. Our main outcomes were biochemical pregnancy, clinical pregnancy, and live birth rates. Five RCTs met our inclusion criteria with a total number of 989 patients. We found endometrial scratch significantly improved the biochemical and clinical pregnancy rates in comparison with the control group among women with previous IUI failure (p < 0.001). Moreover, the live birth rate was significantly increased among the endometrial scratch group (RR = 2.00, 95% CI [1.20, 3.34], p = 0.008). In conclusion, endometrial scratch is effective in improving pregnancy outcomes among women with previous IUI failure. More trials are required to confirm our findings.
AB - The objective of this study was to evaluate the impact of endometrial scratch on the pregnancy rate among women with previous failed intrauterine insemination (IUI). A systematic search was done in PubMed, Cochrane Library, Scopus, and ISI web of science from inception to November 2021. We selected randomized clinical trials (RCTs) that compared endometrial scratch in the intervention group versus placebo or no intervention in the control group among infertile women with previous failure of IUI regarding different pregnancy outcomes. Revman software was utilized for performing our meta-analysis. Our main outcomes were biochemical pregnancy, clinical pregnancy, and live birth rates. Five RCTs met our inclusion criteria with a total number of 989 patients. We found endometrial scratch significantly improved the biochemical and clinical pregnancy rates in comparison with the control group among women with previous IUI failure (p < 0.001). Moreover, the live birth rate was significantly increased among the endometrial scratch group (RR = 2.00, 95% CI [1.20, 3.34], p = 0.008). In conclusion, endometrial scratch is effective in improving pregnancy outcomes among women with previous IUI failure. More trials are required to confirm our findings.
KW - Endometrial scratch
KW - Intrauterine insemination failure
KW - IUI failure
KW - Pregnancy rate
UR - http://www.scopus.com/inward/record.url?scp=85138231808&partnerID=8YFLogxK
U2 - 10.1007/s43032-022-01081-z
DO - 10.1007/s43032-022-01081-z
M3 - Review article
C2 - 36121616
AN - SCOPUS:85138231808
SN - 1933-7191
VL - 30
SP - 1399
EP - 1407
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 5
ER -