TY - JOUR
T1 - The compelling role of allopurinol in hyperuricemia-induced epilepsy
T2 - Unrecognized like tears in rain
AU - AlAseeri, Ali Abdullah
AU - Al-kuraishy, Hayder M.
AU - Al-Gareeb, Ali I.
AU - Ali, Naif H.
AU - Alexiou, Athanasios
AU - Papadakis, Marios
AU - Bahaa, Mostafa M.
AU - Alruwaili, Mubarak
AU - Batiha, Gaber El Saber
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/7
Y1 - 2024/7
N2 - Epilepsy is a common neurological disease characterized by the recurrent, paroxysmal, and unprovoked seizures. It has been shown that hyperuricemia enhances and associated with the development and progression of epilepsy through induction of inflammation and oxidative stress. In addition, uric acid is released within the brain and contributes in the development of neuronal hyperexcitability and epileptic seizure. Brain uric acid acts as damage associated molecular pattern (DAMP) activates the immune response and induce the development of neuroinflammation. Therefore, inhibition of xanthine oxidase by allopurinol may reduce hyperuricemia-induced epileptic seizure and associated oxidative stress and inflammation. However, the underlying mechanism of allopurinol in the epilepsy was not fully elucidated. Therefore, this review aims to revise from published articles the link between hyperuricemia and epilepsy, and how allopurinol inhibits the development of epileptic seizure.
AB - Epilepsy is a common neurological disease characterized by the recurrent, paroxysmal, and unprovoked seizures. It has been shown that hyperuricemia enhances and associated with the development and progression of epilepsy through induction of inflammation and oxidative stress. In addition, uric acid is released within the brain and contributes in the development of neuronal hyperexcitability and epileptic seizure. Brain uric acid acts as damage associated molecular pattern (DAMP) activates the immune response and induce the development of neuroinflammation. Therefore, inhibition of xanthine oxidase by allopurinol may reduce hyperuricemia-induced epileptic seizure and associated oxidative stress and inflammation. However, the underlying mechanism of allopurinol in the epilepsy was not fully elucidated. Therefore, this review aims to revise from published articles the link between hyperuricemia and epilepsy, and how allopurinol inhibits the development of epileptic seizure.
KW - Allopurinol
KW - Epilepsy
KW - Inflammation
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85193577481&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2024.110973
DO - 10.1016/j.brainresbull.2024.110973
M3 - Review article
C2 - 38723694
AN - SCOPUS:85193577481
SN - 0361-9230
VL - 213
JO - Brain Research Bulletin
JF - Brain Research Bulletin
M1 - 110973
ER -