The Anticancer Journey of Liquiritin: Insights into Its Mechanisms and Therapeutic Prospects

Asif Ahmad Bhat; Ehssan Moglad; Muhammad Afzal; Neetu Agrawal; Riya Thapa; Waleed Hassan almalki; Imran Kazmi; Sami I. Alzarea; Haider Ali; Sanjay Sharma; Sachin Kumar Singh; Kamal Dua; Gaurav Gupta

doi:10.2174/0109298673315699240805111122

The Anticancer Journey of Liquiritin: Insights into Its Mechanisms and Therapeutic Prospects

Asif Ahmad Bhat, Ehssan Moglad, Muhammad Afzal, Neetu Agrawal, Riya Thapa, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Haider Ali, Sanjay Sharma, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta

Pharmaceutics

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Liquiritin (LIQ), a bioactive flavonoid from Glycyrrhiza species, has shown significant potential in cancer therapy. LIQ exhibits potent inhibitory effects on various cancer cell types, including breast, lung, liver, and colon cancers, while demonstrating low toxicity towards healthy cells. Its anticancer mechanisms include inducing cell cycle arrest, promoting apoptosis, and modulating inflammation-related pathways. Additionally, LIQ impedes angiogenesis and enhances the efficacy of conventional chemotherapies through sensitization and synergistic effects with other natural compounds and targeted therapies. These multifaceted actions highlight LIQ as a promising candidate for further development as an anticancer agent. This abstract provides an overview of LIQ's chemistry, biological effects, and underlying mechanisms.

Original language	English
Journal	Current Medicinal Chemistry
DOIs	https://doi.org/10.2174/0109298673315699240805111122
State	Accepted/In press - 2024

Keywords

Liquiritin
apoptosis
cancer
chemistry
glycyrrhiza
inflammation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/0109298673315699240805111122

Cite this

@article{2a3e70f32a8f49e5a65014486f4e0d3c,

title = "The Anticancer Journey of Liquiritin: Insights into Its Mechanisms and Therapeutic Prospects",

abstract = "Liquiritin (LIQ), a bioactive flavonoid from Glycyrrhiza species, has shown significant potential in cancer therapy. LIQ exhibits potent inhibitory effects on various cancer cell types, including breast, lung, liver, and colon cancers, while demonstrating low toxicity towards healthy cells. Its anticancer mechanisms include inducing cell cycle arrest, promoting apoptosis, and modulating inflammation-related pathways. Additionally, LIQ impedes angiogenesis and enhances the efficacy of conventional chemotherapies through sensitization and synergistic effects with other natural compounds and targeted therapies. These multifaceted actions highlight LIQ as a promising candidate for further development as an anticancer agent. This abstract provides an overview of LIQ's chemistry, biological effects, and underlying mechanisms.",

keywords = "Liquiritin, apoptosis, cancer, chemistry, glycyrrhiza, inflammation",

author = "Bhat, \{Asif Ahmad\} and Ehssan Moglad and Muhammad Afzal and Neetu Agrawal and Riya Thapa and almalki, \{Waleed Hassan\} and Imran Kazmi and Alzarea, \{Sami I.\} and Haider Ali and Sanjay Sharma and Singh, \{Sachin Kumar\} and Kamal Dua and Gaurav Gupta",

note = "Publisher Copyright: {\textcopyright} 2024 Bentham Science Publishers.",

year = "2024",

doi = "10.2174/0109298673315699240805111122",

language = "English",

journal = "Current Medicinal Chemistry",

issn = "0929-8673",

publisher = "Bentham Science Publishers",

}

TY - JOUR

T1 - The Anticancer Journey of Liquiritin

T2 - Insights into Its Mechanisms and Therapeutic Prospects

AU - Bhat, Asif Ahmad

AU - Moglad, Ehssan

AU - Afzal, Muhammad

AU - Agrawal, Neetu

AU - Thapa, Riya

AU - almalki, Waleed Hassan

AU - Kazmi, Imran

AU - Alzarea, Sami I.

AU - Ali, Haider

AU - Sharma, Sanjay

AU - Singh, Sachin Kumar

AU - Dua, Kamal

AU - Gupta, Gaurav

PY - 2024

Y1 - 2024

N2 - Liquiritin (LIQ), a bioactive flavonoid from Glycyrrhiza species, has shown significant potential in cancer therapy. LIQ exhibits potent inhibitory effects on various cancer cell types, including breast, lung, liver, and colon cancers, while demonstrating low toxicity towards healthy cells. Its anticancer mechanisms include inducing cell cycle arrest, promoting apoptosis, and modulating inflammation-related pathways. Additionally, LIQ impedes angiogenesis and enhances the efficacy of conventional chemotherapies through sensitization and synergistic effects with other natural compounds and targeted therapies. These multifaceted actions highlight LIQ as a promising candidate for further development as an anticancer agent. This abstract provides an overview of LIQ's chemistry, biological effects, and underlying mechanisms.

AB - Liquiritin (LIQ), a bioactive flavonoid from Glycyrrhiza species, has shown significant potential in cancer therapy. LIQ exhibits potent inhibitory effects on various cancer cell types, including breast, lung, liver, and colon cancers, while demonstrating low toxicity towards healthy cells. Its anticancer mechanisms include inducing cell cycle arrest, promoting apoptosis, and modulating inflammation-related pathways. Additionally, LIQ impedes angiogenesis and enhances the efficacy of conventional chemotherapies through sensitization and synergistic effects with other natural compounds and targeted therapies. These multifaceted actions highlight LIQ as a promising candidate for further development as an anticancer agent. This abstract provides an overview of LIQ's chemistry, biological effects, and underlying mechanisms.

KW - Liquiritin

KW - apoptosis

KW - cancer

KW - chemistry

KW - glycyrrhiza

KW - inflammation

UR - http://www.scopus.com/inward/record.url?scp=85208415419&partnerID=8YFLogxK

U2 - 10.2174/0109298673315699240805111122

DO - 10.2174/0109298673315699240805111122

M3 - Review article

C2 - 39162280

AN - SCOPUS:85208415419

SN - 0929-8673

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

ER -

The Anticancer Journey of Liquiritin: Insights into Its Mechanisms and Therapeutic Prospects

Abstract

Keywords

UN SDGs

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