Temperature dependent solubility studies of brigatinib in some pure solvents useful in dosage form development

Saad M. Alshahrani; Muqtader Mohammad; M. D. Khalid Anwer; Farhat Fatima; Abdullah S. Alshetaili; Ahmed Alalaiwe; Bader B. Alsulays; Faiyaz Shakeel

doi:10.32383/appdr/94616

Temperature dependent solubility studies of brigatinib in some pure solvents useful in dosage form development

Saad M. Alshahrani, Muqtader Mohammad, M. D. Khalid Anwer, Farhat Fatima, Abdullah S. Alshetaili, Ahmed Alalaiwe, Bader B. Alsulays, Faiyaz Shakeel

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In the current study, thermodynamic dissolution of brigatinib in six pure solvents namely, water, ethanol, isopropyl myristate (IPM), poly(ethylene glycol)-400 (PEG-400), dichloromethane (DCM) and ethyl acetate (EA) at (298.2-323.2 K) temperature and 0.1 MPa atm. pressure were carried out using flask shaking technique. The mole-fraction solubility of brigatinib was obtained greatest in IPM (6.09 × 10^-2) and least in water (3.12 × 10^-6) at 298.2 K. Experimentally obtained solubilities values of brigatinib were regressed using adapted Apelblat equation with root mean square deviations in the range of 1.91 to 4.67 in all solvents and similar trends were observed with increased the temperature. The solubility data generated in this investigation could be helpful for investigator for analysis/dosage form development of brigatinib.

Original language	English
Pages (from-to)	225-232
Number of pages	8
Journal	Acta Poloniae Pharmaceutica
Volume	76
Issue number	2
DOIs	https://doi.org/10.32383/appdr/94616
State	Published - 2019

Keywords

Apelblat model
Curve fitting
Lung cancer
Mole fraction solubility
Thermodynamic dissolution

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10.32383/appdr/94616

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title = "Temperature dependent solubility studies of brigatinib in some pure solvents useful in dosage form development",

abstract = "In the current study, thermodynamic dissolution of brigatinib in six pure solvents namely, water, ethanol, isopropyl myristate (IPM), poly(ethylene glycol)-400 (PEG-400), dichloromethane (DCM) and ethyl acetate (EA) at (298.2-323.2 K) temperature and 0.1 MPa atm. pressure were carried out using flask shaking technique. The mole-fraction solubility of brigatinib was obtained greatest in IPM (6.09 × 10-2) and least in water (3.12 × 10-6) at 298.2 K. Experimentally obtained solubilities values of brigatinib were regressed using adapted Apelblat equation with root mean square deviations in the range of 1.91 to 4.67 in all solvents and similar trends were observed with increased the temperature. The solubility data generated in this investigation could be helpful for investigator for analysis/dosage form development of brigatinib.",

keywords = "Apelblat model, Curve fitting, Lung cancer, Mole fraction solubility, Thermodynamic dissolution",

author = "Alshahrani, \{Saad M.\} and Muqtader Mohammad and \{Khalid Anwer\}, \{M. D.\} and Farhat Fatima and Alshetaili, \{Abdullah S.\} and Ahmed Alalaiwe and Alsulays, \{Bader B.\} and Faiyaz Shakeel",

year = "2019",

doi = "10.32383/appdr/94616",

language = "English",

volume = "76",

pages = "225--232",

journal = "Acta Poloniae Pharmaceutica",

issn = "0001-6837",

publisher = "Polish Pharmaceutical Society",

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TY - JOUR

T1 - Temperature dependent solubility studies of brigatinib in some pure solvents useful in dosage form development

AU - Alshahrani, Saad M.

AU - Mohammad, Muqtader

AU - Khalid Anwer, M. D.

AU - Fatima, Farhat

AU - Alshetaili, Abdullah S.

AU - Alalaiwe, Ahmed

AU - Alsulays, Bader B.

AU - Shakeel, Faiyaz

PY - 2019

Y1 - 2019

N2 - In the current study, thermodynamic dissolution of brigatinib in six pure solvents namely, water, ethanol, isopropyl myristate (IPM), poly(ethylene glycol)-400 (PEG-400), dichloromethane (DCM) and ethyl acetate (EA) at (298.2-323.2 K) temperature and 0.1 MPa atm. pressure were carried out using flask shaking technique. The mole-fraction solubility of brigatinib was obtained greatest in IPM (6.09 × 10-2) and least in water (3.12 × 10-6) at 298.2 K. Experimentally obtained solubilities values of brigatinib were regressed using adapted Apelblat equation with root mean square deviations in the range of 1.91 to 4.67 in all solvents and similar trends were observed with increased the temperature. The solubility data generated in this investigation could be helpful for investigator for analysis/dosage form development of brigatinib.

AB - In the current study, thermodynamic dissolution of brigatinib in six pure solvents namely, water, ethanol, isopropyl myristate (IPM), poly(ethylene glycol)-400 (PEG-400), dichloromethane (DCM) and ethyl acetate (EA) at (298.2-323.2 K) temperature and 0.1 MPa atm. pressure were carried out using flask shaking technique. The mole-fraction solubility of brigatinib was obtained greatest in IPM (6.09 × 10-2) and least in water (3.12 × 10-6) at 298.2 K. Experimentally obtained solubilities values of brigatinib were regressed using adapted Apelblat equation with root mean square deviations in the range of 1.91 to 4.67 in all solvents and similar trends were observed with increased the temperature. The solubility data generated in this investigation could be helpful for investigator for analysis/dosage form development of brigatinib.

KW - Apelblat model

KW - Curve fitting

KW - Lung cancer

KW - Mole fraction solubility

KW - Thermodynamic dissolution

UR - http://www.scopus.com/inward/record.url?scp=85068667694&partnerID=8YFLogxK

U2 - 10.32383/appdr/94616

DO - 10.32383/appdr/94616

M3 - Article

AN - SCOPUS:85068667694

SN - 0001-6837

VL - 76

SP - 225

EP - 232

JO - Acta Poloniae Pharmaceutica

JF - Acta Poloniae Pharmaceutica

IS - 2

ER -

Temperature dependent solubility studies of brigatinib in some pure solvents useful in dosage form development

Abstract

Keywords

UN SDGs

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