Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

Mohammed B. Alshammari; Mohamed Ramadan; Ashraf A. Aly; Essmat M. El-Sheref; Md Afroz Bakht; Mahmoud A.A. Ibrahim; Ahmed M. Shawky

doi:10.1016/j.molstruc.2020.129649

Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

Mohammed B. Alshammari, Mohamed Ramadan, Ashraf A. Aly, Essmat M. El-Sheref, Md Afroz Bakht, Mahmoud A.A. Ibrahim, Ahmed M. Shawky

Chemistry

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15 Scopus citations

Abstract

We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M^pro) comparable toRemdesivir.

Original language	English
Article number	129649
Journal	Journal of Molecular Structure
Volume	1230
DOIs	https://doi.org/10.1016/j.molstruc.2020.129649
State	Published - 15 Apr 2021

Keywords

Molecular docking
N-substituted-2-quinolonylacetohydrazides
Nmr
Quinolone
Remdesivir

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.molstruc.2020.129649

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title = "Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents",

abstract = "We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (Mpro) comparable toRemdesivir.",

keywords = "Molecular docking, N-substituted-2-quinolonylacetohydrazides, Nmr, Quinolone, Remdesivir",

author = "Alshammari, \{Mohammed B.\} and Mohamed Ramadan and Aly, \{Ashraf A.\} and El-Sheref, \{Essmat M.\} and Bakht, \{Md Afroz\} and Ibrahim, \{Mahmoud A.A.\} and Shawky, \{Ahmed M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2021",

month = apr,

day = "15",

doi = "10.1016/j.molstruc.2020.129649",

language = "English",

volume = "1230",

journal = "Journal of Molecular Structure",

issn = "0022-2860",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

AU - Alshammari, Mohammed B.

AU - Ramadan, Mohamed

AU - Aly, Ashraf A.

AU - El-Sheref, Essmat M.

AU - Bakht, Md Afroz

AU - Ibrahim, Mahmoud A.A.

AU - Shawky, Ahmed M.

PY - 2021/4/15

Y1 - 2021/4/15

N2 - We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (Mpro) comparable toRemdesivir.

AB - We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (Mpro) comparable toRemdesivir.

KW - Molecular docking

KW - N-substituted-2-quinolonylacetohydrazides

KW - Nmr

KW - Quinolone

KW - Remdesivir

UR - http://www.scopus.com/inward/record.url?scp=85097082472&partnerID=8YFLogxK

U2 - 10.1016/j.molstruc.2020.129649

DO - 10.1016/j.molstruc.2020.129649

M3 - Article

AN - SCOPUS:85097082472

SN - 0022-2860

VL - 1230

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 129649

ER -

Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

Abstract

Keywords

UN SDGs

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