TY - JOUR
T1 - Synthesis of novel 3-substituted pyridothienopyrimidine derivatives with biological evaluation as antimicrobial agents
AU - El-Essawy, Farag A.
AU - Boshta, Nader M.
AU - El-Sawaf, Ayman K.
AU - Nassar, Amal A.
AU - Khalafallah, Mohamed S.
N1 - Publisher Copyright:
© 2016, Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-3(4H)-yl}acetohydrazide(5) with a variety of active reagents and chemicals. Structures of the newly synthesized compounds were established based on spectral data. The resulting pyridothienopyrimidine derivatives were evaluated for their possible antimicrobial activity and some of them represent a new class of potentially antimicrobial compounds, especially compounds 9 and 18 which displayed the highest activity against Gram-positive bacteria, Gram-negative bacteria, and Fungi in MIC range of 0.12―1.95 μg/mL.
AB - Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-3(4H)-yl}acetohydrazide(5) with a variety of active reagents and chemicals. Structures of the newly synthesized compounds were established based on spectral data. The resulting pyridothienopyrimidine derivatives were evaluated for their possible antimicrobial activity and some of them represent a new class of potentially antimicrobial compounds, especially compounds 9 and 18 which displayed the highest activity against Gram-positive bacteria, Gram-negative bacteria, and Fungi in MIC range of 0.12―1.95 μg/mL.
KW - Antimicrobial
KW - Nitrogen-containing heterocycle
KW - Pyridothienopyrimidine
KW - Thieno[2,3-b]pyridine
UR - http://www.scopus.com/inward/record.url?scp=85002142093&partnerID=8YFLogxK
U2 - 10.1007/s40242-016-6218-z
DO - 10.1007/s40242-016-6218-z
M3 - Article
AN - SCOPUS:85002142093
SN - 1005-9040
VL - 32
SP - 967
EP - 972
JO - Chemical Research in Chinese Universities
JF - Chemical Research in Chinese Universities
IS - 6
ER -