Synthesis of New Zirconium Magnetic Nanocomposite as a Bioactive Agent and Green Catalyst in the Four-Component Synthesis of a Novel Multi-Ring Compound Containing Pyrazole Derivatives

Mohammed Asiri, Ahmed Ghalib Abdulsalam, Mustafa Kahtan, Fahad Alsaikhan, Issa Farhan, Dhameer A. Mutlak, Salema K. Hadrawi, Muath Suliman, Ritamaria Di Lorenzo, Sonia Laneri

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

New nanocomposites containing zirconium were synthesized using microwave irradiation. Their structure was confirmed by vibrating sample magnetometer (VSM) curves, X-ray diffraction (XRD) patterns, scanning electron microscope (SEM) and transmission electron microscopy (TEM) images, Fourier transform infrared spectroscopy (FT-IR), and Brunauer–Emmett–Teller (BET) N2 adsorption/desorption isotherms. After the structure confirmation of the zirconium magnetic nanocomposite, the catalytic properties in the synthesis of pyrazole derivatives were investigated. Next, the biological activities of the zirconium magnetic nanocomposite, such as the antibacterial and antifungal activities, were investigated. The research results showed that the zirconium magnetic nanocomposite has high catalytic properties and can be used as a magnetic nanocatalyst for synthesizing heterocyclic compounds such as pyrazole derivatives in addition to having high biological properties. The unique properties of the nanoparticles can be attributed to their synthesis method and microwave radiation.

Original languageEnglish
Article number4468
JournalNanomaterials
Volume12
Issue number24
DOIs
StatePublished - Dec 2022

Keywords

  • antibacterial activity
  • antifungal activity
  • bioactive agent
  • four-component reaction
  • green catalyst
  • pyrazole derivatives
  • zirconium magnetic nanocomposite

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