TY - JOUR
T1 - Synthesis of Natural Nano-Hydroxyapatite from Snail Shells and Its Biological Activity
T2 - Antimicrobial, Antibiofilm, and Biocompatibility
AU - Ahmed, Hanaa Y.
AU - Safwat, Nesreen
AU - Shehata, Reda
AU - Althubaiti, Eman Hillal
AU - Kareem, Sayed
AU - Atef, Ahmed
AU - Qari, Sameer H.
AU - Aljahani, Amani H.
AU - Al-Meshal, Areej Suliman
AU - Youssef, Mahmoud
AU - Sami, Rokayya
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4
Y1 - 2022/4
N2 - Hydroxyapatite nanoparticles (HAn) have been produced as biomaterial from biowaste, especially snail shells (Atactodea glabrata). It is critical to recycle the waste product in a biomedical application to overcome antibiotic resistance as well as biocompatibility with normal tissues. Moreover, EDX, TEM, and FT-IR analyses have been used to characterize snail shells and HAn. The particle size of HAn is about 15.22 nm. Furthermore, higher inhibitory activity was observed from HAn than the reference compounds against all tested organisms. The synthesized HAn has shown the lowest MIC values of about 7.8, 0.97, 3.9, 0.97, and 25 µg/mL for S. aureus, B. subtilis, K. pneumonia, C. albicans, and E. coli, respectively. In addition, the HAn displayed potent antibiofilm against S. aureus and B. subtilis. According to the MTT, snail shell and HAn had a minor influence on the viability of HFS-4 cells. Consequently, it could be concluded that some components of waste, such as snail shells, have economic value and can be recycled as a source of CaO to produce HAn, which is a promising candidate material for biomedical applications.
AB - Hydroxyapatite nanoparticles (HAn) have been produced as biomaterial from biowaste, especially snail shells (Atactodea glabrata). It is critical to recycle the waste product in a biomedical application to overcome antibiotic resistance as well as biocompatibility with normal tissues. Moreover, EDX, TEM, and FT-IR analyses have been used to characterize snail shells and HAn. The particle size of HAn is about 15.22 nm. Furthermore, higher inhibitory activity was observed from HAn than the reference compounds against all tested organisms. The synthesized HAn has shown the lowest MIC values of about 7.8, 0.97, 3.9, 0.97, and 25 µg/mL for S. aureus, B. subtilis, K. pneumonia, C. albicans, and E. coli, respectively. In addition, the HAn displayed potent antibiofilm against S. aureus and B. subtilis. According to the MTT, snail shell and HAn had a minor influence on the viability of HFS-4 cells. Consequently, it could be concluded that some components of waste, such as snail shells, have economic value and can be recycled as a source of CaO to produce HAn, which is a promising candidate material for biomedical applications.
KW - antibiofilm
KW - antimicrobial
KW - biocompatibility
KW - hydroxyapatite
KW - nanoparticles
KW - snail shell
UR - http://www.scopus.com/inward/record.url?scp=85128647080&partnerID=8YFLogxK
U2 - 10.3390/membranes12040408
DO - 10.3390/membranes12040408
M3 - Article
AN - SCOPUS:85128647080
SN - 2077-0375
VL - 12
JO - Membranes
JF - Membranes
IS - 4
M1 - 408
ER -
