Synthesis, Characterization, and Determination of Antifungal Activity of Acacia arabica Mediated Metal Doped Copper Oxide Nanocomposites

Metallic nanoparticles (NPs) can be synthesized using a range of methodologies, include chemi-cal, physical, and biological processes. Current study undergoes the antimicrobial activity of the copper oxide nanocomposites synthesized by the sol-gel method with the help of Acacia arabica plant extract. About 1 g of copper sulphate was dissolved in 100 mL of distilled water and stirred with aid of heating till the copper sulphate may get fully dissolved. The particle size and lattice of the nanocomposites was determined by XRD. The different functional groups were identified by means of the FTIR. The presence of Cu and O in CuO NCs was confirmed using EDAX analysis. Antifungal activity was investigated by using the disc diffusion method. The characteristic peaks of diffraction obtained at 2θ values of 37o, 39o, 48o, 53o, 58o, 61o, 68 o and 73o, respectively, for the planes of (002), (111), (-202), (020), (202), (-113), (-311), (220), and (-222) which clearly represent the monoclinic phase of CuO nano-composite while the peaks at 44 o and 63o correspond to the plane orientation (131) and (220), TGA curve of CuO nanocomposites showed three-step decomposition. The major mass loss was observed in the range of 400 to 800 ºC. EDX confirms the presence of the Au, and Cuo in the nanocomposites. Aspergillus niger showed 18 mm zone of inhibition with 10 g/mL and 21mm was shown by Candida albicans. Copper oxide nanocomposites showed the outstanding antifungal activity and can be considered the best antifungal therapy.