TY - JOUR
T1 - Synthesis and reactions of 3-pyrrolidinones
AU - Amer, Fathy Abdel Kader
AU - Hammouda, Metwally
AU - El-Ahl, Abdel Aziz Sayed
AU - Abdel-Wahab, Bakr Fathy
PY - 2008/11
Y1 - 2008/11
N2 - (Chemical Equation Presented) This review presents a survey of the synthetic methods and reactions of 3-pyrrolidinones I (R = H, alkyl, acyl, ester; R1 = H, alkyl, cyano, ester, etc). 3-Pyrrolidinones are synthetically versatiles substrate, as they can be used for synthesis of a large variety of heterocyclic compounds, such as indoles and 5-deazapteroic acid analogues and as a raw material for drug synthesis. The high reactivity of an active methylene group next to the carbonyl of the pyrrolidine ring is useful for various syntheses.
AB - (Chemical Equation Presented) This review presents a survey of the synthetic methods and reactions of 3-pyrrolidinones I (R = H, alkyl, acyl, ester; R1 = H, alkyl, cyano, ester, etc). 3-Pyrrolidinones are synthetically versatiles substrate, as they can be used for synthesis of a large variety of heterocyclic compounds, such as indoles and 5-deazapteroic acid analogues and as a raw material for drug synthesis. The high reactivity of an active methylene group next to the carbonyl of the pyrrolidine ring is useful for various syntheses.
UR - http://www.scopus.com/inward/record.url?scp=57749187669&partnerID=8YFLogxK
U2 - 10.1002/jhet.5570450602
DO - 10.1002/jhet.5570450602
M3 - Review article
AN - SCOPUS:57749187669
SN - 0022-152X
VL - 45
SP - 1549
EP - 1569
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 6
ER -