Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

Neelam Bharti; Kakul Husain; M. T. Gonzalez Garza; Delia E. Cruz-Vega; J. Castro-Garza; Benito D. Mata-Cardenas; Fehmida Naqvi; Amir Azam

doi:10.1016/S0960-894X(02)00703-5

Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

Neelam Bharti
, Kakul Husain
, M. T. Gonzalez Garza
, Delia E. Cruz-Vega
, J. Castro-Garza
, Benito D. Mata-Cardenas
, Fehmida Naqvi
, Amir Azam

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N⁴-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.

Original language	English
Pages (from-to)	3475-3478
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(02)00703-5
State	Published - Dec 2002
Externally published	Yes

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10.1016/S0960-894X(02)00703-5

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title = "Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives",

abstract = "Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N4-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.",

author = "Neelam Bharti and Kakul Husain and \{Gonzalez Garza\}, \{M. T.\} and Cruz-Vega, \{Delia E.\} and J. Castro-Garza and Mata-Cardenas, \{Benito D.\} and Fehmida Naqvi and Amir Azam",

year = "2002",

month = dec,

doi = "10.1016/S0960-894X(02)00703-5",

language = "English",

volume = "12",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

AU - Bharti, Neelam

AU - Husain, Kakul

AU - Gonzalez Garza, M. T.

AU - Cruz-Vega, Delia E.

AU - Castro-Garza, J.

AU - Mata-Cardenas, Benito D.

AU - Naqvi, Fehmida

AU - Azam, Amir

PY - 2002/12

Y1 - 2002/12

N2 - Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N4-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.

AB - Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N4-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.

UR - https://www.scopus.com/pages/publications/0036888378

U2 - 10.1016/S0960-894X(02)00703-5

DO - 10.1016/S0960-894X(02)00703-5

M3 - Article

C2 - 12419387

AN - SCOPUS:0036888378

SN - 0960-894X

VL - 12

SP - 3475

EP - 3478

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

Abstract

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