TY - JOUR
T1 - Synthesis and antimycobacterial activity of 4-[5-(substituted phenyl)-4, 5-dihydro-3-isoxazolyl]-2-methylphenols
AU - Shaharyar, Mohammad
AU - Ali, Mohamed Ashraf
AU - Bakht, Mohammad Afroz
AU - Murugan, Vel
PY - 2008/6
Y1 - 2008/6
N2 - Compounds based on the isoxazoline moiety were screened for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H37R (MTB), and INH (isoniazid) resistant Mycobacterium tuberculosis (INHR-MTB) using the agar dilution method and bactec 460. Among the synthesized compounds, 4-[5-(4-bromophenyl) -4,5-dihydro-3-isoxazolyl]-2-methylphenol (4l) was found to be the most active agent against MTB and INHR-MTB with minimum inhibitory concentration of 0.62 μM. When compared to INH, compound (4l) was 1.12 fold and 3.0 fold more active against MTB and INHR-MTB, respectively.
AB - Compounds based on the isoxazoline moiety were screened for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H37R (MTB), and INH (isoniazid) resistant Mycobacterium tuberculosis (INHR-MTB) using the agar dilution method and bactec 460. Among the synthesized compounds, 4-[5-(4-bromophenyl) -4,5-dihydro-3-isoxazolyl]-2-methylphenol (4l) was found to be the most active agent against MTB and INHR-MTB with minimum inhibitory concentration of 0.62 μM. When compared to INH, compound (4l) was 1.12 fold and 3.0 fold more active against MTB and INHR-MTB, respectively.
KW - Antimycobacterial agent
KW - Isoxazolyl
KW - Mycobacterium tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=46649090939&partnerID=8YFLogxK
U2 - 10.1080/14756360701652559
DO - 10.1080/14756360701652559
M3 - Article
C2 - 18569351
AN - SCOPUS:46649090939
SN - 1475-6366
VL - 23
SP - 432
EP - 436
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
IS - 3
ER -
