Abstract
Compounds based on the isoxazoline moiety were screened for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H37R (MTB), and INH (isoniazid) resistant Mycobacterium tuberculosis (INHR-MTB) using the agar dilution method and bactec 460. Among the synthesized compounds, 4-[5-(4-bromophenyl) -4,5-dihydro-3-isoxazolyl]-2-methylphenol (4l) was found to be the most active agent against MTB and INHR-MTB with minimum inhibitory concentration of 0.62 μM. When compared to INH, compound (4l) was 1.12 fold and 3.0 fold more active against MTB and INHR-MTB, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 432-436 |
| Number of pages | 5 |
| Journal | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2008 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Antimycobacterial agent
- Isoxazolyl
- Mycobacterium tuberculosis
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