Abstract
The present work reports the effect of radiation cross-linking on aqueous solution of 4-acryloyl morpho-line (ACMO)/acrylic acid (AA) in the presence of flutamide (FLT), an anticancer drug. Use of a γ-irradiation process within 5 kGy provided an insoluble hydrogel. Ultraviolet-visible absorption, fluorescence spectroscopy, and Fourier transform infrared spectroscopy were employed to study the complex formation of FLT with ACMO and AA. The ability of the prepared ACMO/AA-based hydrogels to be used as drug carriers for anticancer-specific drug delivery system was estimated using FLT as a model drug. In vitro drug release studies in a pH 7 buffer solution show that 20%-30% of the FLT was continuously released from the FLT-incorporated ACMO/AA hydrogel within 1 day, followed by a gradual release upon 7 days under in vitro non-degradation hydrogel conditions. The recognition affinity of the ACMO/AA/FLT hydrogel is increased when synthesized in a high-concentration template solution.
| Original language | English |
|---|---|
| Pages (from-to) | 407-414 |
| Number of pages | 8 |
| Journal | Macromolecular Research |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2012 |
Keywords
- γ-irradiation
- Drug
- Fluorescence
- Flutamide
- Hydrogel
- Sustained-release
