Sustained delivery of hydrocortisone acetate by CS/N-vinyl-2-pyrrolidone/ CaCO3 microparticle hybrid hydrogels

Tahia B. Mostafa; Samia El-Sigeny; Manal F. Abou Taleb

doi:10.1002/pc.22765

Sustained delivery of hydrocortisone acetate by CS/N-vinyl-2-pyrrolidone/ CaCO₃ microparticle hybrid hydrogels

Tahia B. Mostafa, Samia El-Sigeny, Manal F. Abou Taleb

Chemistry

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The goal of this research is to develop a composite hydrogel system for sustained release of therapeutic agents. The hybrid hydrogels were prepared by radiation crosslinking on aqueous solution of Chitosan (CS)/N-vinyl-2- pyrrolidone (NVP) with different loads of CaCO₃ in the presence of hydrocortisone acetate (HCA), an anti-inflammatory drugs. Physical characteristics of CS/NVP/CaCO₃ were studied using X-ray diffraction (XRD) and infrared spectrophotometery (IR). The porous structure of resulted hydrogel was confirmed by SEM micrographs. The effect of doses and calcium carbonate amount on the swelling of the hydrogels was investigated. The ability of the prepared CS/NVP/CaCO₃-based hybrid hydrogels to be used as drug carriers for anti-inflammatory-specific drug delivery system was estimated using HCA as a model drug. POLYM. COMPOS., 35:1176-1183, 2014.

Original language	English
Pages (from-to)	1176-1183
Number of pages	8
Journal	Polymer Composites
Volume	35
Issue number	6
DOIs	https://doi.org/10.1002/pc.22765
State	Published - Jun 2014

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abstract = "The goal of this research is to develop a composite hydrogel system for sustained release of therapeutic agents. The hybrid hydrogels were prepared by radiation crosslinking on aqueous solution of Chitosan (CS)/N-vinyl-2- pyrrolidone (NVP) with different loads of CaCO3 in the presence of hydrocortisone acetate (HCA), an anti-inflammatory drugs. Physical characteristics of CS/NVP/CaCO3 were studied using X-ray diffraction (XRD) and infrared spectrophotometery (IR). The porous structure of resulted hydrogel was confirmed by SEM micrographs. The effect of doses and calcium carbonate amount on the swelling of the hydrogels was investigated. The ability of the prepared CS/NVP/CaCO3-based hybrid hydrogels to be used as drug carriers for anti-inflammatory-specific drug delivery system was estimated using HCA as a model drug. POLYM. COMPOS., 35:1176-1183, 2014.",

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AU - El-Sigeny, Samia

AU - Abou Taleb, Manal F.

PY - 2014/6

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AB - The goal of this research is to develop a composite hydrogel system for sustained release of therapeutic agents. The hybrid hydrogels were prepared by radiation crosslinking on aqueous solution of Chitosan (CS)/N-vinyl-2- pyrrolidone (NVP) with different loads of CaCO3 in the presence of hydrocortisone acetate (HCA), an anti-inflammatory drugs. Physical characteristics of CS/NVP/CaCO3 were studied using X-ray diffraction (XRD) and infrared spectrophotometery (IR). The porous structure of resulted hydrogel was confirmed by SEM micrographs. The effect of doses and calcium carbonate amount on the swelling of the hydrogels was investigated. The ability of the prepared CS/NVP/CaCO3-based hybrid hydrogels to be used as drug carriers for anti-inflammatory-specific drug delivery system was estimated using HCA as a model drug. POLYM. COMPOS., 35:1176-1183, 2014.

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Sustained delivery of hydrocortisone acetate by CS/N-vinyl-2-pyrrolidone/ CaCO₃ microparticle hybrid hydrogels

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