TY - JOUR
T1 - Structural, functional, molecular, and biological evaluation of novel triterpenoids isolated from Helichrysum stoechas (L.) Moench. Collected from Mediterranean Sea bank
T2 - Misurata- Libya
AU - Sarfaraj Hussain, Md
AU - Azam, Faizul
AU - Ahmed Eldarrat, Hanan
AU - Haque Haque, Anzarul
AU - Khalid, Mohammad
AU - Zaheen Hassan, Mohd
AU - Ali, Mohammed
AU - Arif, Muhammad
AU - Ahmad, Irfan
AU - Zaman, Gaffar
AU - Alabdallah, Nadiyah M.
AU - Saeed, Mohd
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/6
Y1 - 2022/6
N2 - Helichrysum stoechas (L.) Moench (Family Compositae) is a medicinal herb endowed with several pharmacological activities. Ethanolic extract of the aerial parts of the plant was used for the isolation of lignoceric acid (HS-02), lanost-5- en-3β-ol- 26-oic acid (HS-03), and lanost-5-en-26-oic acid-3β-olyl palmitate (HS-04). All molecules were screened for anti-inflammatory and analgesic activities at 5 and 10 mg/kg body weight doses, and the TEST program assessed their toxicity. The molecular interaction profile with numerous anti-inflammatory drug targets was investigated by molecular docking. Compounds HS-03 and HS-04 showed a significant reduction in paw volume compared to the control group challenged with carrageenan in the rats, and prolongation of the paw licking/jumping and reduction in the number of writhes was noted after the injection of acetic acid in mice. In a hot plate test, all compounds showed significant pain inhibition. These findings might aid in the development of anti-inflammatory and anti-analgesic therapies.
AB - Helichrysum stoechas (L.) Moench (Family Compositae) is a medicinal herb endowed with several pharmacological activities. Ethanolic extract of the aerial parts of the plant was used for the isolation of lignoceric acid (HS-02), lanost-5- en-3β-ol- 26-oic acid (HS-03), and lanost-5-en-26-oic acid-3β-olyl palmitate (HS-04). All molecules were screened for anti-inflammatory and analgesic activities at 5 and 10 mg/kg body weight doses, and the TEST program assessed their toxicity. The molecular interaction profile with numerous anti-inflammatory drug targets was investigated by molecular docking. Compounds HS-03 and HS-04 showed a significant reduction in paw volume compared to the control group challenged with carrageenan in the rats, and prolongation of the paw licking/jumping and reduction in the number of writhes was noted after the injection of acetic acid in mice. In a hot plate test, all compounds showed significant pain inhibition. These findings might aid in the development of anti-inflammatory and anti-analgesic therapies.
KW - Analgesic
KW - Anti-inflammatory
KW - Compositae
KW - Helichrysum stoechas (L.) Moench
KW - Lanostane triterpenoids
KW - Molecular docking
UR - http://www.scopus.com/inward/record.url?scp=85125844243&partnerID=8YFLogxK
U2 - 10.1016/j.arabjc.2022.103818
DO - 10.1016/j.arabjc.2022.103818
M3 - Article
AN - SCOPUS:85125844243
SN - 1878-5352
VL - 15
JO - Arabian Journal of Chemistry
JF - Arabian Journal of Chemistry
IS - 6
M1 - 103818
ER -