TY - JOUR
T1 - Solubility of bioactive compound hesperidin in six pure solvents at (298.15 to 333.15) K
AU - Anwer, Md Khalid
AU - Al-Shdefat, Ramadan
AU - Jamil, Shahid
AU - Alam, Prawez
AU - Abdel-Kader, Maged S.
AU - Shakeel, Faiyaz
PY - 2014/6/12
Y1 - 2014/6/12
N2 - Temperature-dependent solubility data of bioactive compound hesperidin has not been reported in any solvent in the literature so far. Therefore, the aim of the current study was to measure the solubility of bioactive compound hesperidin in six different pure solvents namely water, ethanol, isopropyl alcohol (IPA), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), and 1-butanol from (298.15 to 333.15) K using the shake flask method. The experimental solubilities of hesperidin were regressed by Apelblat equation with root-mean-square deviations in the range of 6.32·10-7 to 0.184 in all solvents investigated. The correlation coefficients in pure solvents were observed in the range of 0.995 to 0.999. The mole fraction solubility of hesperidin was found to be higher in PEG-400 (6.33·10 -3 at 298.15 K) and PG (5.35·10-4 at 298.15 K) as compared to water (1.47·10-7 at 298.15 K), ethanol (3.45·10-5 at 298.15 K), IPA (1.53·10-5 at 298.15 K), and 1-butanol (3.15·10-4 at 298.15 K). The data of the current study could be useful in crystallization/purification and formulation development of hesperidin in the chemical/pharmaceutical industry.
AB - Temperature-dependent solubility data of bioactive compound hesperidin has not been reported in any solvent in the literature so far. Therefore, the aim of the current study was to measure the solubility of bioactive compound hesperidin in six different pure solvents namely water, ethanol, isopropyl alcohol (IPA), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), and 1-butanol from (298.15 to 333.15) K using the shake flask method. The experimental solubilities of hesperidin were regressed by Apelblat equation with root-mean-square deviations in the range of 6.32·10-7 to 0.184 in all solvents investigated. The correlation coefficients in pure solvents were observed in the range of 0.995 to 0.999. The mole fraction solubility of hesperidin was found to be higher in PEG-400 (6.33·10 -3 at 298.15 K) and PG (5.35·10-4 at 298.15 K) as compared to water (1.47·10-7 at 298.15 K), ethanol (3.45·10-5 at 298.15 K), IPA (1.53·10-5 at 298.15 K), and 1-butanol (3.15·10-4 at 298.15 K). The data of the current study could be useful in crystallization/purification and formulation development of hesperidin in the chemical/pharmaceutical industry.
UR - http://www.scopus.com/inward/record.url?scp=84902303880&partnerID=8YFLogxK
U2 - 10.1021/je500206w
DO - 10.1021/je500206w
M3 - Article
AN - SCOPUS:84902303880
SN - 0021-9568
VL - 59
SP - 2065
EP - 2069
JO - Journal of Chemical and Engineering Data
JF - Journal of Chemical and Engineering Data
IS - 6
ER -
