Solubility and Dissolution Enhancement of Dexibuprofen by Inclusion Complexation with Cyclodextrin

Rabia Munir; Usama Mashood; Sajid Asghar; Ikram Ullah Khan; Muhammad Irfan; Sana Inam; Nayyer Islam; Nyla Ajaz; Shahzadi Filza Hassan; Saniya Anwar; Pervaiz A. Shah; Muhammad Saleem; Muhammad Shahid Iqbal; Haroon Khalid Syed

Solubility and Dissolution Enhancement of Dexibuprofen by Inclusion Complexation with Cyclodextrin

Rabia Munir, Usama Mashood, Sajid Asghar, Ikram Ullah Khan, Muhammad Irfan, Sana Inam, Nayyer Islam, Nyla Ajaz, Shahzadi Filza Hassan, Saniya Anwar, Pervaiz A. Shah, Muhammad Saleem, Muhammad Shahid Iqbal, Haroon Khalid Syed

Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

SUMMARY. The solubility enhancement ability of different methods was compared by using dexibuprofen (DEX) as a model drug. Binary inclusion complexes of DEX were prepared with beta cyclodextrin (βCD) at weight ratio of 1:1,1:2 and 1:4 by physical trituration (PT), kneading (KN) and solvent evaporation (SE) method. The phase solubility studies illustrated that DEX solubility increased proportionally with an increase in βCD concentration. The solubility of DEX was significantly higher when complexed with βCD by KN method. DEX-βCD complexes were examined critically by using infrared (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). FTIR and XRD did not show any significant difference between DEX-βCD complexes prepared by PT and KN method. DSC thermograms of DEX-βCD prepared by KN method were showed a decrease in the intensity of endothermic peak of DEX more than PT method. XRD results indicated that DEX shifted to less crystalline state when complexed with βCD. In conclusion, βCD is suitable to increase the solubility of DEX.

Original language	English
Pages (from-to)	235-243
Number of pages	9
Journal	Latin American Journal of Pharmacy
Volume	41
Issue number	1
State	Published - 2022

Keywords

binary inclusion complexes
Cyclodextrin
Dexibuprofen
in vitro release
solubility

Cite this

@article{16e88d402d124ad6b4f1c0339987d7f3,

title = "Solubility and Dissolution Enhancement of Dexibuprofen by Inclusion Complexation with Cyclodextrin",

abstract = "SUMMARY. The solubility enhancement ability of different methods was compared by using dexibuprofen (DEX) as a model drug. Binary inclusion complexes of DEX were prepared with beta cyclodextrin (βCD) at weight ratio of 1:1,1:2 and 1:4 by physical trituration (PT), kneading (KN) and solvent evaporation (SE) method. The phase solubility studies illustrated that DEX solubility increased proportionally with an increase in βCD concentration. The solubility of DEX was significantly higher when complexed with βCD by KN method. DEX-βCD complexes were examined critically by using infrared (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). FTIR and XRD did not show any significant difference between DEX-βCD complexes prepared by PT and KN method. DSC thermograms of DEX-βCD prepared by KN method were showed a decrease in the intensity of endothermic peak of DEX more than PT method. XRD results indicated that DEX shifted to less crystalline state when complexed with βCD. In conclusion, βCD is suitable to increase the solubility of DEX.",

keywords = "binary inclusion complexes, Cyclodextrin, Dexibuprofen, in vitro release, solubility",

author = "Rabia Munir and Usama Mashood and Sajid Asghar and Khan, \{Ikram Ullah\} and Muhammad Irfan and Sana Inam and Nayyer Islam and Nyla Ajaz and Hassan, \{Shahzadi Filza\} and Saniya Anwar and Shah, \{Pervaiz A.\} and Muhammad Saleem and Iqbal, \{Muhammad Shahid\} and Syed, \{Haroon Khalid\}",

year = "2022",

language = "English",

volume = "41",

pages = "235--243",

journal = "Latin American Journal of Pharmacy",

issn = "0326-2383",

publisher = "Colegio de Farmaceuticos de la Provincia de Buenos Aires",

number = "1",

}

TY - JOUR

T1 - Solubility and Dissolution Enhancement of Dexibuprofen by Inclusion Complexation with Cyclodextrin

AU - Munir, Rabia

AU - Mashood, Usama

AU - Asghar, Sajid

AU - Khan, Ikram Ullah

AU - Irfan, Muhammad

AU - Inam, Sana

AU - Islam, Nayyer

AU - Ajaz, Nyla

AU - Hassan, Shahzadi Filza

AU - Anwar, Saniya

AU - Shah, Pervaiz A.

AU - Saleem, Muhammad

AU - Iqbal, Muhammad Shahid

AU - Syed, Haroon Khalid

PY - 2022

Y1 - 2022

N2 - SUMMARY. The solubility enhancement ability of different methods was compared by using dexibuprofen (DEX) as a model drug. Binary inclusion complexes of DEX were prepared with beta cyclodextrin (βCD) at weight ratio of 1:1,1:2 and 1:4 by physical trituration (PT), kneading (KN) and solvent evaporation (SE) method. The phase solubility studies illustrated that DEX solubility increased proportionally with an increase in βCD concentration. The solubility of DEX was significantly higher when complexed with βCD by KN method. DEX-βCD complexes were examined critically by using infrared (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). FTIR and XRD did not show any significant difference between DEX-βCD complexes prepared by PT and KN method. DSC thermograms of DEX-βCD prepared by KN method were showed a decrease in the intensity of endothermic peak of DEX more than PT method. XRD results indicated that DEX shifted to less crystalline state when complexed with βCD. In conclusion, βCD is suitable to increase the solubility of DEX.

AB - SUMMARY. The solubility enhancement ability of different methods was compared by using dexibuprofen (DEX) as a model drug. Binary inclusion complexes of DEX were prepared with beta cyclodextrin (βCD) at weight ratio of 1:1,1:2 and 1:4 by physical trituration (PT), kneading (KN) and solvent evaporation (SE) method. The phase solubility studies illustrated that DEX solubility increased proportionally with an increase in βCD concentration. The solubility of DEX was significantly higher when complexed with βCD by KN method. DEX-βCD complexes were examined critically by using infrared (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). FTIR and XRD did not show any significant difference between DEX-βCD complexes prepared by PT and KN method. DSC thermograms of DEX-βCD prepared by KN method were showed a decrease in the intensity of endothermic peak of DEX more than PT method. XRD results indicated that DEX shifted to less crystalline state when complexed with βCD. In conclusion, βCD is suitable to increase the solubility of DEX.

KW - binary inclusion complexes

KW - Cyclodextrin

KW - Dexibuprofen

KW - in vitro release

KW - solubility

UR - http://www.scopus.com/inward/record.url?scp=85123682900&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85123682900

SN - 0326-2383

VL - 41

SP - 235

EP - 243

JO - Latin American Journal of Pharmacy

JF - Latin American Journal of Pharmacy

IS - 1

ER -

Solubility and Dissolution Enhancement of Dexibuprofen by Inclusion Complexation with Cyclodextrin

Abstract

Keywords

Other files and links

Fingerprint

Cite this