TY - JOUR
T1 - Sodium alginate-based drug delivery for diabetes management
T2 - A review
AU - Shaikh, Mohammad Arshad Javed
AU - Gupta, Gaurav
AU - Afzal, Obaid
AU - Gupta, Madan Mohan
AU - Goyal, Ahsas
AU - Altamimi, Abdulmalik Saleh Alfawaz
AU - Alzarea, Sami I.
AU - Almalki, Waleed Hassan
AU - Kazmi, Imran
AU - Negi, Poonam
AU - Singh, Sachin Kumar
AU - Dua, Kamal
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Diabetes mellitus (DM) is among the biggest global health problems of the 21st century, which is characterised by insufficient insulin secretion and results in the augmentation of blood sugar levels. The current foundation of hyperglycemia therapy is oral antihyperglycemic medications like biguanides, sulphonylureas, α-glucosidase inhibitors, peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists, sodium-glucose co-transporter 2 (SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and others. Many naturally occurring substances have shown promise in treating hyperglycemia. Inadequate prologitivity of action, restricted bioavailability, site specificity, and dose-related side effects are some problems with currently available anti-diabetic medications. Sodium alginate has shown promise as a drug delivery mechanism, potentially solving issues with current therapies for several substances. This review summarizes the research on the efficacy of drug delivery systems based on alginate for transporting oral hypoglycemic medicines, phytochemicals, and insulin for treating hyperglycemia.
AB - Diabetes mellitus (DM) is among the biggest global health problems of the 21st century, which is characterised by insufficient insulin secretion and results in the augmentation of blood sugar levels. The current foundation of hyperglycemia therapy is oral antihyperglycemic medications like biguanides, sulphonylureas, α-glucosidase inhibitors, peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists, sodium-glucose co-transporter 2 (SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and others. Many naturally occurring substances have shown promise in treating hyperglycemia. Inadequate prologitivity of action, restricted bioavailability, site specificity, and dose-related side effects are some problems with currently available anti-diabetic medications. Sodium alginate has shown promise as a drug delivery mechanism, potentially solving issues with current therapies for several substances. This review summarizes the research on the efficacy of drug delivery systems based on alginate for transporting oral hypoglycemic medicines, phytochemicals, and insulin for treating hyperglycemia.
KW - Diabetes
KW - Drug delivery
KW - Hyperglycemia
KW - Insulin
KW - Polysaccharides
KW - Sodium alginate
UR - http://www.scopus.com/inward/record.url?scp=85150031237&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2023.123986
DO - 10.1016/j.ijbiomac.2023.123986
M3 - Review article
C2 - 36906199
AN - SCOPUS:85150031237
SN - 0141-8130
VL - 236
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 123986
ER -
