TY - JOUR
T1 - Quercetin as a multi-targeted therapeutic agent in breast cancer
T2 - molecular targets and therapeutic potential
AU - Hjazi, Ahmed
AU - Mohammed, Sumaya Nadhim
AU - Abosaoda, Munthar Kadhim
AU - Ahmad, Irfan
AU - Rekha, M. M.
AU - Kundlas, Mayank
AU - Ullah, Muhammad Ikram
AU - Abd, Baydaa
AU - Ray, Subhashree
AU - Nathiya, Deepak
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
PY - 2025/8
Y1 - 2025/8
N2 - Breast cancer is a worldwide serious health issue with constantly recurring issues of drug resistance, toxicity, and recurrence. These limitations have prompted research on various drug compounds, particularly those derived from plants. Quercetin is one such compound, a flavonol dietary component. This review aims to synthesize the existing evidence on the molecular pathways through which quercetin regulates various oncogenic cascades in breast cancer, including the PI3K/Akt/mTOR, Wnt/β-catenin, JAK/STAT, AMPK, and non-coding RNA pathways. The review also highlights the therapeutic potential of quercetin to potentiate the efficacy of conventional chemotherapies and suppress drug resistance and thus suggests the potential of quercetin as a combinational therapy agent. In contrast to previous reviews, this study presents a new and up-to-date description of the pleiotropic effects of quercetin in breast cancer pathobiology, bridging mechanistic understanding with translational applicability.
AB - Breast cancer is a worldwide serious health issue with constantly recurring issues of drug resistance, toxicity, and recurrence. These limitations have prompted research on various drug compounds, particularly those derived from plants. Quercetin is one such compound, a flavonol dietary component. This review aims to synthesize the existing evidence on the molecular pathways through which quercetin regulates various oncogenic cascades in breast cancer, including the PI3K/Akt/mTOR, Wnt/β-catenin, JAK/STAT, AMPK, and non-coding RNA pathways. The review also highlights the therapeutic potential of quercetin to potentiate the efficacy of conventional chemotherapies and suppress drug resistance and thus suggests the potential of quercetin as a combinational therapy agent. In contrast to previous reviews, this study presents a new and up-to-date description of the pleiotropic effects of quercetin in breast cancer pathobiology, bridging mechanistic understanding with translational applicability.
KW - Apoptosis
KW - Breast carcinoma
KW - Malignancy
KW - Quercetin
KW - Signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=105011280275&partnerID=8YFLogxK
U2 - 10.1007/s12032-025-02907-x
DO - 10.1007/s12032-025-02907-x
M3 - Review article
C2 - 40694163
AN - SCOPUS:105011280275
SN - 1357-0560
VL - 42
JO - Medical Oncology
JF - Medical Oncology
IS - 8
M1 - 365
ER -
