Protective Effect of Zingiber officinale Rhizomes Against Experimental Induced Ulcers in Diabetic Rats

Phool Chandra; RoomiKhan; Neetu Sachan; Mustafa Halawi; Ahad Amer Alsaiari; Mazen Almehmadi; Mehnaz Kamal; Talha Jawaid; Mohammad Asif

doi:10.1007/s11094-022-02760-6

Protective Effect of Zingiber officinale Rhizomes Against Experimental Induced Ulcers in Diabetic Rats

Phool Chandra, RoomiKhan, Neetu Sachan, Mustafa Halawi, Ahad Amer Alsaiari, Mazen Almehmadi, Mehnaz Kamal, Talha Jawaid, Mohammad Asif

Pharmaceutical Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This study was commenced to assess the antiulcer effect of the ethanol extract of Zingiber officinale rhizomes (EEZOR) against pylorus ligation-, aspirin-, and ethanol-induced ulcer models in diabetic rats. Diabetes and ulcers were induced in rats as per reported methods. The ulcer index, free acidity, pH and total acidity in pylorus ligated induced ulcer model in diabetic rats was examined using variable dosage of EEZOR and the ulcer index, % protection, and antioxidant activity parameters were studied. It was found that EEZOR inhibited the acid secretion in diabetic rats (p < 0.001) as compared to control rats with diabetes and ulcers. EEZOR also showed significant mucosal protection and antioxidant properties. It has been concluded that the EEZOR protective effect against different model ulcers in diabetic rats may be due to the presence of flavonoids and polyphenolic compound in ginger.

Original language	English
Pages (from-to)	1107-1115
Number of pages	9
Journal	Pharmaceutical Chemistry Journal
Volume	56
Issue number	8
DOIs	https://doi.org/10.1007/s11094-022-02760-6
State	Published - Nov 2022

Keywords

diabetes
ginger
protective effect
ulcer, antioxidant
Zingiber officinale

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11094-022-02760-6

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title = "Protective Effect of Zingiber officinale Rhizomes Against Experimental Induced Ulcers in Diabetic Rats",

abstract = "This study was commenced to assess the antiulcer effect of the ethanol extract of Zingiber officinale rhizomes (EEZOR) against pylorus ligation-, aspirin-, and ethanol-induced ulcer models in diabetic rats. Diabetes and ulcers were induced in rats as per reported methods. The ulcer index, free acidity, pH and total acidity in pylorus ligated induced ulcer model in diabetic rats was examined using variable dosage of EEZOR and the ulcer index, \% protection, and antioxidant activity parameters were studied. It was found that EEZOR inhibited the acid secretion in diabetic rats (p < 0.001) as compared to control rats with diabetes and ulcers. EEZOR also showed significant mucosal protection and antioxidant properties. It has been concluded that the EEZOR protective effect against different model ulcers in diabetic rats may be due to the presence of flavonoids and polyphenolic compound in ginger.",

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author = "Phool Chandra and RoomiKhan and Neetu Sachan and Mustafa Halawi and Alsaiari, \{Ahad Amer\} and Mazen Almehmadi and Mehnaz Kamal and Talha Jawaid and Mohammad Asif",

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doi = "10.1007/s11094-022-02760-6",

language = "English",

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T1 - Protective Effect of Zingiber officinale Rhizomes Against Experimental Induced Ulcers in Diabetic Rats

AU - Chandra, Phool

AU - RoomiKhan,

AU - Sachan, Neetu

AU - Halawi, Mustafa

AU - Alsaiari, Ahad Amer

AU - Almehmadi, Mazen

AU - Kamal, Mehnaz

AU - Jawaid, Talha

AU - Asif, Mohammad

PY - 2022/11

Y1 - 2022/11

N2 - This study was commenced to assess the antiulcer effect of the ethanol extract of Zingiber officinale rhizomes (EEZOR) against pylorus ligation-, aspirin-, and ethanol-induced ulcer models in diabetic rats. Diabetes and ulcers were induced in rats as per reported methods. The ulcer index, free acidity, pH and total acidity in pylorus ligated induced ulcer model in diabetic rats was examined using variable dosage of EEZOR and the ulcer index, % protection, and antioxidant activity parameters were studied. It was found that EEZOR inhibited the acid secretion in diabetic rats (p < 0.001) as compared to control rats with diabetes and ulcers. EEZOR also showed significant mucosal protection and antioxidant properties. It has been concluded that the EEZOR protective effect against different model ulcers in diabetic rats may be due to the presence of flavonoids and polyphenolic compound in ginger.

AB - This study was commenced to assess the antiulcer effect of the ethanol extract of Zingiber officinale rhizomes (EEZOR) against pylorus ligation-, aspirin-, and ethanol-induced ulcer models in diabetic rats. Diabetes and ulcers were induced in rats as per reported methods. The ulcer index, free acidity, pH and total acidity in pylorus ligated induced ulcer model in diabetic rats was examined using variable dosage of EEZOR and the ulcer index, % protection, and antioxidant activity parameters were studied. It was found that EEZOR inhibited the acid secretion in diabetic rats (p < 0.001) as compared to control rats with diabetes and ulcers. EEZOR also showed significant mucosal protection and antioxidant properties. It has been concluded that the EEZOR protective effect against different model ulcers in diabetic rats may be due to the presence of flavonoids and polyphenolic compound in ginger.

KW - diabetes

KW - ginger

KW - protective effect

KW - ulcer, antioxidant

KW - Zingiber officinale

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U2 - 10.1007/s11094-022-02760-6

DO - 10.1007/s11094-022-02760-6

M3 - Article

AN - SCOPUS:85142173391

SN - 0091-150X

VL - 56

SP - 1107

EP - 1115

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 8

ER -

Protective Effect of Zingiber officinale Rhizomes Against Experimental Induced Ulcers in Diabetic Rats

Abstract

Keywords

UN SDGs

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