Prophylactic Effects of Coriander Aqueous Extract on Carbendazim - Induced Renal Toxicity in Male Rats

Somaya Y. Shalaby; Mohamed A. Akela; Mustafa Karhib; Youssef Hussein; Mohamed Rabea; Ehab Tousson

doi:10.13005/bpj/2786

Prophylactic Effects of Coriander Aqueous Extract on Carbendazim - Induced Renal Toxicity in Male Rats

Somaya Y. Shalaby, Mohamed A. Akela, Mustafa Karhib, Youssef Hussein, Mohamed Rabea, Ehab Tousson

Biology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A broad spectrum carbamate fungicide called carbendazim (Carb) that is very crucial for preventing plant diseases. and is one of the most pervasive environmental pollutants with serious implications for both human and animal health. In the current study, the role of Coriandrum sativum seeds extract (CSE) on carbendazim induced rats renal toxicity. Carb induced significant elevation in serum creatinine, urea, potassium, kidney malondialdehyde (MDA), nitric oxide (NO), renal injury, PCNA and significant depletion in serum sodium, calcium, renal glutathione (GSH). Treatments of Carb with CSE (CSE+Carb and/or Carb+CSE) improved these parameters and reduced renal toxicity with best results for Carb+CSE than CSE+Carb. Serum phosphorus revealed no significant changes between different groups. The above findings support the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.

Original language	English
Pages (from-to)	2113-2121
Number of pages	9
Journal	Biomedical and Pharmacology Journal
Volume	16
Issue number	4
DOIs	https://doi.org/10.13005/bpj/2786
State	Published - 2023

Keywords

Antioxidant
Carbendazim
Coriandrum sativum
Kidney

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.13005/bpj/2786

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title = "Prophylactic Effects of Coriander Aqueous Extract on Carbendazim - Induced Renal Toxicity in Male Rats",

abstract = "A broad spectrum carbamate fungicide called carbendazim (Carb) that is very crucial for preventing plant diseases. and is one of the most pervasive environmental pollutants with serious implications for both human and animal health. In the current study, the role of Coriandrum sativum seeds extract (CSE) on carbendazim induced rats renal toxicity. Carb induced significant elevation in serum creatinine, urea, potassium, kidney malondialdehyde (MDA), nitric oxide (NO), renal injury, PCNA and significant depletion in serum sodium, calcium, renal glutathione (GSH). Treatments of Carb with CSE (CSE+Carb and/or Carb+CSE) improved these parameters and reduced renal toxicity with best results for Carb+CSE than CSE+Carb. Serum phosphorus revealed no significant changes between different groups. The above findings support the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.",

keywords = "Antioxidant, Carbendazim, Coriandrum sativum, Kidney",

author = "Shalaby, \{Somaya Y.\} and Akela, \{Mohamed A.\} and Mustafa Karhib and Youssef Hussein and Mohamed Rabea and Ehab Tousson",

year = "2023",

doi = "10.13005/bpj/2786",

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pages = "2113--2121",

journal = "Biomedical and Pharmacology Journal",

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T1 - Prophylactic Effects of Coriander Aqueous Extract on Carbendazim - Induced Renal Toxicity in Male Rats

AU - Shalaby, Somaya Y.

AU - Akela, Mohamed A.

AU - Karhib, Mustafa

AU - Hussein, Youssef

AU - Rabea, Mohamed

AU - Tousson, Ehab

PY - 2023

Y1 - 2023

N2 - A broad spectrum carbamate fungicide called carbendazim (Carb) that is very crucial for preventing plant diseases. and is one of the most pervasive environmental pollutants with serious implications for both human and animal health. In the current study, the role of Coriandrum sativum seeds extract (CSE) on carbendazim induced rats renal toxicity. Carb induced significant elevation in serum creatinine, urea, potassium, kidney malondialdehyde (MDA), nitric oxide (NO), renal injury, PCNA and significant depletion in serum sodium, calcium, renal glutathione (GSH). Treatments of Carb with CSE (CSE+Carb and/or Carb+CSE) improved these parameters and reduced renal toxicity with best results for Carb+CSE than CSE+Carb. Serum phosphorus revealed no significant changes between different groups. The above findings support the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.

AB - A broad spectrum carbamate fungicide called carbendazim (Carb) that is very crucial for preventing plant diseases. and is one of the most pervasive environmental pollutants with serious implications for both human and animal health. In the current study, the role of Coriandrum sativum seeds extract (CSE) on carbendazim induced rats renal toxicity. Carb induced significant elevation in serum creatinine, urea, potassium, kidney malondialdehyde (MDA), nitric oxide (NO), renal injury, PCNA and significant depletion in serum sodium, calcium, renal glutathione (GSH). Treatments of Carb with CSE (CSE+Carb and/or Carb+CSE) improved these parameters and reduced renal toxicity with best results for Carb+CSE than CSE+Carb. Serum phosphorus revealed no significant changes between different groups. The above findings support the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.

KW - Antioxidant

KW - Carbendazim

KW - Coriandrum sativum

KW - Kidney

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DO - 10.13005/bpj/2786

M3 - Article

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SN - 0974-6242

VL - 16

SP - 2113

EP - 2121

JO - Biomedical and Pharmacology Journal

JF - Biomedical and Pharmacology Journal

IS - 4

ER -

Prophylactic Effects of Coriander Aqueous Extract on Carbendazim - Induced Renal Toxicity in Male Rats

Abstract

Keywords

UN SDGs

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