Preparation and evaluation of spray dried rosuvastatin calcium-PVP microparticles for the improvement of serum lipid profile

Ramadan Al-Shdefat; Md Khalid Anwer; Mohamed H. Fayed; Badar B. Alsulays; Hesham M. Tawfeek; Rehab F. Abdel-Rahman; Gamal A. Soliman

doi:10.1016/j.jddst.2019.101342

Preparation and evaluation of spray dried rosuvastatin calcium-PVP microparticles for the improvement of serum lipid profile

Ramadan Al-Shdefat, Md Khalid Anwer, Mohamed H. Fayed, Badar B. Alsulays, Hesham M. Tawfeek, Rehab F. Abdel-Rahman, Gamal A. Soliman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The poor physicochemical properties of rosuvastatin calcium (ROS) remains a challenge for dosage form development. In the present study, we explore the development of spray dried ROS loaded PVP microparticles to improve the release of ROS as well as the anti-hyperlipidemic efficacy. The ROS loaded PVP microparticles (F1–F3) were developed by spray drying method with a range of particle size (1.26–1.67 μm), PDI (0.138-0.267), PDE (78 ± 3.2 to 89 ± 4.1%), PDL and (14.8 ± 1.2 to 39.4 ± 3.3%). The ROS loaded microparticles (F3) was optimized based on preliminary characterization and further evaluated for DSC, FTIR, SEM, in vitro release studies and anti-hyperlipidemic activity. Overall, It was proved that spray dried PVP microparticles was efficient carrier to deliver rosuvastatin with improved serum lipid profile of hyperlipidemic rats.

Original language	English
Article number	101342
Journal	Journal of Drug Delivery Science and Technology
Volume	55
DOIs	https://doi.org/10.1016/j.jddst.2019.101342
State	Published - Feb 2020

Keywords

Lipid profile
Microparticles
PVP
Rosuvastatin
Spray drying

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@article{f540e695fd2f4e07abf0251b5298c0c3,

title = "Preparation and evaluation of spray dried rosuvastatin calcium-PVP microparticles for the improvement of serum lipid profile",

abstract = "The poor physicochemical properties of rosuvastatin calcium (ROS) remains a challenge for dosage form development. In the present study, we explore the development of spray dried ROS loaded PVP microparticles to improve the release of ROS as well as the anti-hyperlipidemic efficacy. The ROS loaded PVP microparticles (F1–F3) were developed by spray drying method with a range of particle size (1.26–1.67 μm), PDI (0.138-0.267), PDE (78 ± 3.2 to 89 ± 4.1\%), PDL and (14.8 ± 1.2 to 39.4 ± 3.3\%). The ROS loaded microparticles (F3) was optimized based on preliminary characterization and further evaluated for DSC, FTIR, SEM, in vitro release studies and anti-hyperlipidemic activity. Overall, It was proved that spray dried PVP microparticles was efficient carrier to deliver rosuvastatin with improved serum lipid profile of hyperlipidemic rats.",

keywords = "Lipid profile, Microparticles, PVP, Rosuvastatin, Spray drying",

author = "Ramadan Al-Shdefat and Anwer, \{Md Khalid\} and Fayed, \{Mohamed H.\} and Alsulays, \{Badar B.\} and Tawfeek, \{Hesham M.\} and Abdel-Rahman, \{Rehab F.\} and Soliman, \{Gamal A.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2020",

month = feb,

doi = "10.1016/j.jddst.2019.101342",

language = "English",

volume = "55",

journal = "Journal of Drug Delivery Science and Technology",

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T1 - Preparation and evaluation of spray dried rosuvastatin calcium-PVP microparticles for the improvement of serum lipid profile

AU - Al-Shdefat, Ramadan

AU - Anwer, Md Khalid

AU - Fayed, Mohamed H.

AU - Alsulays, Badar B.

AU - Tawfeek, Hesham M.

AU - Abdel-Rahman, Rehab F.

AU - Soliman, Gamal A.

PY - 2020/2

Y1 - 2020/2

N2 - The poor physicochemical properties of rosuvastatin calcium (ROS) remains a challenge for dosage form development. In the present study, we explore the development of spray dried ROS loaded PVP microparticles to improve the release of ROS as well as the anti-hyperlipidemic efficacy. The ROS loaded PVP microparticles (F1–F3) were developed by spray drying method with a range of particle size (1.26–1.67 μm), PDI (0.138-0.267), PDE (78 ± 3.2 to 89 ± 4.1%), PDL and (14.8 ± 1.2 to 39.4 ± 3.3%). The ROS loaded microparticles (F3) was optimized based on preliminary characterization and further evaluated for DSC, FTIR, SEM, in vitro release studies and anti-hyperlipidemic activity. Overall, It was proved that spray dried PVP microparticles was efficient carrier to deliver rosuvastatin with improved serum lipid profile of hyperlipidemic rats.

AB - The poor physicochemical properties of rosuvastatin calcium (ROS) remains a challenge for dosage form development. In the present study, we explore the development of spray dried ROS loaded PVP microparticles to improve the release of ROS as well as the anti-hyperlipidemic efficacy. The ROS loaded PVP microparticles (F1–F3) were developed by spray drying method with a range of particle size (1.26–1.67 μm), PDI (0.138-0.267), PDE (78 ± 3.2 to 89 ± 4.1%), PDL and (14.8 ± 1.2 to 39.4 ± 3.3%). The ROS loaded microparticles (F3) was optimized based on preliminary characterization and further evaluated for DSC, FTIR, SEM, in vitro release studies and anti-hyperlipidemic activity. Overall, It was proved that spray dried PVP microparticles was efficient carrier to deliver rosuvastatin with improved serum lipid profile of hyperlipidemic rats.

KW - Lipid profile

KW - Microparticles

KW - PVP

KW - Rosuvastatin

KW - Spray drying

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U2 - 10.1016/j.jddst.2019.101342

DO - 10.1016/j.jddst.2019.101342

M3 - Article

AN - SCOPUS:85074152906

SN - 1773-2247

VL - 55

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

M1 - 101342

ER -

Preparation and evaluation of spray dried rosuvastatin calcium-PVP microparticles for the improvement of serum lipid profile

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Keywords

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