Prenylated flavonoids from Commiphora opobalsamum stem bark

Ali A. El-Gamal; Shaza M. Al-Massarani; Wael M. Abdel-Mageed; Amina El-Shaibany; Hassan M. Al-Mahbashi; Omer A. Basudan; Farid A. Badria; Mansour S. Al-Said; Maged S. Abdel-Kader

doi:10.1016/j.phytochem.2017.05.014

Prenylated flavonoids from Commiphora opobalsamum stem bark

Ali A. El-Gamal, Shaza M. Al-Massarani, Wael M. Abdel-Mageed, Amina El-Shaibany, Hassan M. Al-Mahbashi, Omer A. Basudan, Farid A. Badria, Mansour S. Al-Said, Maged S. Abdel-Kader

Fharmacognosy

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A–E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC₅₀ values of 8 and 12 μg/mL, respectively.

Original language	English
Pages (from-to)	80-85
Number of pages	6
Journal	Phytochemistry
Volume	141
DOIs	https://doi.org/10.1016/j.phytochem.2017.05.014
State	Published - Sep 2017

Keywords

Burseraceae
Commiphora opobalsamum
Cytotoxic activity
Flavonoids
Prenylated flavonoids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2017.05.014

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@article{296a162fa9064824ac7159d20084574c,

title = "Prenylated flavonoids from Commiphora opobalsamum stem bark",

abstract = "A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A–E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 μg/mL, respectively.",

keywords = "Burseraceae, Commiphora opobalsamum, Cytotoxic activity, Flavonoids, Prenylated flavonoids",

author = "El-Gamal, \{Ali A.\} and Al-Massarani, \{Shaza M.\} and Abdel-Mageed, \{Wael M.\} and Amina El-Shaibany and Al-Mahbashi, \{Hassan M.\} and Basudan, \{Omer A.\} and Badria, \{Farid A.\} and Al-Said, \{Mansour S.\} and Abdel-Kader, \{Maged S.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = sep,

doi = "10.1016/j.phytochem.2017.05.014",

language = "English",

volume = "141",

pages = "80--85",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Prenylated flavonoids from Commiphora opobalsamum stem bark

AU - El-Gamal, Ali A.

AU - Al-Massarani, Shaza M.

AU - Abdel-Mageed, Wael M.

AU - El-Shaibany, Amina

AU - Al-Mahbashi, Hassan M.

AU - Basudan, Omer A.

AU - Badria, Farid A.

AU - Al-Said, Mansour S.

AU - Abdel-Kader, Maged S.

PY - 2017/9

Y1 - 2017/9

N2 - A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A–E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 μg/mL, respectively.

AB - A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A–E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 μg/mL, respectively.

KW - Burseraceae

KW - Commiphora opobalsamum

KW - Cytotoxic activity

KW - Flavonoids

KW - Prenylated flavonoids

UR - http://www.scopus.com/inward/record.url?scp=85020021909&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2017.05.014

DO - 10.1016/j.phytochem.2017.05.014

M3 - Article

C2 - 28582635

AN - SCOPUS:85020021909

SN - 0031-9422

VL - 141

SP - 80

EP - 85

JO - Phytochemistry

JF - Phytochemistry

ER -

Prenylated flavonoids from Commiphora opobalsamum stem bark

Abstract

Keywords

UN SDGs

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