Potentiometric Determination of Moxifloxacin by Solid-Contact ISEs in Wastewater Effluents

In recent years, the use of ion-selective membranes in the sensing and assessment of environmental contaminants has become a critical goal. Using sodium tetraphenylborate (TPB) and phosphotungstic acid (PTA) as ion-pairing agents, two sensitive and selective sensors were manufactured to evaluate the electrochemical response of moxifloxacin hydrochloride (MOX). The optimal electrochemical behavior was attained by fine-tuning all assay parameters. The manufactured membranes’ performance was optimal in a pH range from 1.0 to 5.0 with a linearity between 1 × 10⁻⁶ M and 1 × 10⁻² M. The MOX–TPB and MOX–PTA membrane electrodes have Nernstian slopes of 59.2 ± 0.60 mV/decade and 58.4 ± 0.50 mV/decade, respectively. The proposed method was used to determine MOX in its pure form as well as real pharmaceutical wastewater effluents. The fabri-cated electrodes were effectively applied for the sensitive and selective determination of MOX in actual wastewater effluents without the need for any pre-treatment processes.