TY - JOUR
T1 - Plant-based secondary metabolites as natural remedies
T2 - a comprehensive review on terpenes and their therapeutic applications
AU - Khanam, Sheeba
AU - Mishra, Pooja
AU - Faruqui, Tabrez
AU - Alam, Pravej
AU - Albalawi, Thamer
AU - Siddiqui, Faiza
AU - Rafi, Zeeshan
AU - Khan, Salman
N1 - Publisher Copyright:
Copyright © 2025 Khanam, Mishra, Faruqui, Alam, Albalawi, Siddiqui, Rafi and Khan.
PY - 2025
Y1 - 2025
N2 - Terpenes are among the most diverse kinds of natural products because of their remarkable chemical variety. Numerous biological characteristics of terpenoids have been documented, including their antibacterial, antifungal, antiviral, antihyperglycemic, anti-inflammatory, and antiparasitic effects, as well as their cancer chemopreventive benefits. Additionally, terpenes are utilized in the manufacturing of organic solvents, varnishes, inks, adhesives, synthetic polymers, natural rubbers, cleaning supplies, biofuels, insecticides, and food and beverage items. Terpenes are therefore highly valued in modern medicine, pharmacy, nutraceuticals, cosmetics, and other fields. Plant oils, including terpenes, have been used to treat a variety of diseases without a full understanding of the roles or modes of action of particular bioactive substances. Many of these compounds are only present in nature in extremely small amounts; thus, methods such as metabolic engineering and synthetic biology are used to harvest them in large quantities in order to produce enough medicine. This comprehensive review aims to elucidate the biochemistry, phytochemical properties, and pharmacological activities of terpenes in metabolic disorders.
AB - Terpenes are among the most diverse kinds of natural products because of their remarkable chemical variety. Numerous biological characteristics of terpenoids have been documented, including their antibacterial, antifungal, antiviral, antihyperglycemic, anti-inflammatory, and antiparasitic effects, as well as their cancer chemopreventive benefits. Additionally, terpenes are utilized in the manufacturing of organic solvents, varnishes, inks, adhesives, synthetic polymers, natural rubbers, cleaning supplies, biofuels, insecticides, and food and beverage items. Terpenes are therefore highly valued in modern medicine, pharmacy, nutraceuticals, cosmetics, and other fields. Plant oils, including terpenes, have been used to treat a variety of diseases without a full understanding of the roles or modes of action of particular bioactive substances. Many of these compounds are only present in nature in extremely small amounts; thus, methods such as metabolic engineering and synthetic biology are used to harvest them in large quantities in order to produce enough medicine. This comprehensive review aims to elucidate the biochemistry, phytochemical properties, and pharmacological activities of terpenes in metabolic disorders.
KW - antibiotics
KW - cancer
KW - natural compounds
KW - plant-based therapy
KW - terpenes
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=105007077642&partnerID=8YFLogxK
U2 - 10.3389/fphar.2025.1587215
DO - 10.3389/fphar.2025.1587215
M3 - Review article
AN - SCOPUS:105007077642
SN - 1663-9812
VL - 16
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 1587215
ER -