Phytoconstituents of Zingiber officinale as New Leads for the Design and Development of Novel Antidengue Agents: An In-silico Analysis

Dengue fever is a mosquito-borne tropical disease causing severe febrile illness as well as hemorrhagic fever. Unfortunately, there are currently no effective treatments for dengue. Recent in-vitro studies have demonstrated that the extract from ginger (Zingiber officinale) might be a promising source for the development of novel anti-dengue drug candidates. Therefore, the aim of this study was to identify potential leads from ginger that can be optimized toward the development of novel antiviral agents against dengue. In silico drug-likeness parameters have also been investigated for filtering out the likelihood of poor drug absorption or brain penetration. Based on docking scores and binding interactions, some compounds have emerged as potential lead molecules against the dengue virus.