Pathogenic role of 25-hydroxycholesterol in cancer development and progression

Sura Salman Ejam; Raed Obaid Saleh; Maria Jade Catalan Opulencia; Mazin A.A. Najm; Aziza Makhmudova; Abduladheem Turki Jalil; Walid Kamal Abdelbasset; Moaed E. Al-Gazally; Ali Thaeer Hammid; Yasser Fakri Mustafa; Sergushina Elena Sergeevna; Sajad Karampoor; Rasoul Mirzaei

doi:10.2217/fon-2022-0819

Pathogenic role of 25-hydroxycholesterol in cancer development and progression

Sura Salman Ejam, Raed Obaid Saleh, Maria Jade Catalan Opulencia, Mazin A.A. Najm, Aziza Makhmudova, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Moaed E. Al-Gazally, Ali Thaeer Hammid, Yasser Fakri Mustafa, Sergushina Elena Sergeevna, Sajad Karampoor, Rasoul Mirzaei

Physical Therapy and Health Rehabilitation

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol. 25-HC is a crucial component in various biological activities, including cholesterol metabolism. In recent years, growing evidence has shown that 25-HC performs a critical function in the etiology of cancer, infectious diseases and autoimmune disorders. This review will summarize the latest findings regarding 25-HC, including its biogenesis, immunomodulatory properties and role in innate/adaptive immunity, inflammation and the development of various types of cancer.

Original language	English
Pages (from-to)	4415-4442
Number of pages	28
Journal	Future Oncology
Volume	18
Issue number	39
DOIs	https://doi.org/10.2217/fon-2022-0819
State	Published - 1 Dec 2022

Keywords

25-HC
cancer
immunity
immunometabolism
inflammation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fon-2022-0819

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Ejam, S. S., Saleh, R. O., Catalan Opulencia, M. J., Najm, M. A. A., Makhmudova, A., Jalil, A. T., Abdelbasset, W. K., Al-Gazally, M. E., Hammid, A. T., Mustafa, Y. F., Sergeevna, S. E., Karampoor, S., & Mirzaei, R. (2022). Pathogenic role of 25-hydroxycholesterol in cancer development and progression. Future Oncology, 18(39), 4415-4442. https://doi.org/10.2217/fon-2022-0819

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title = "Pathogenic role of 25-hydroxycholesterol in cancer development and progression",

abstract = "Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol. 25-HC is a crucial component in various biological activities, including cholesterol metabolism. In recent years, growing evidence has shown that 25-HC performs a critical function in the etiology of cancer, infectious diseases and autoimmune disorders. This review will summarize the latest findings regarding 25-HC, including its biogenesis, immunomodulatory properties and role in innate/adaptive immunity, inflammation and the development of various types of cancer.",

keywords = "25-HC, cancer, immunity, immunometabolism, inflammation",

author = "Ejam, \{Sura Salman\} and Saleh, \{Raed Obaid\} and \{Catalan Opulencia\}, \{Maria Jade\} and Najm, \{Mazin A.A.\} and Aziza Makhmudova and Jalil, \{Abduladheem Turki\} and Abdelbasset, \{Walid Kamal\} and Al-Gazally, \{Moaed E.\} and Hammid, \{Ali Thaeer\} and Mustafa, \{Yasser Fakri\} and Sergeevna, \{Sergushina Elena\} and Sajad Karampoor and Rasoul Mirzaei",

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doi = "10.2217/fon-2022-0819",

language = "English",

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T1 - Pathogenic role of 25-hydroxycholesterol in cancer development and progression

AU - Ejam, Sura Salman

AU - Saleh, Raed Obaid

AU - Catalan Opulencia, Maria Jade

AU - Najm, Mazin A.A.

AU - Makhmudova, Aziza

AU - Jalil, Abduladheem Turki

AU - Abdelbasset, Walid Kamal

AU - Al-Gazally, Moaed E.

AU - Hammid, Ali Thaeer

AU - Mustafa, Yasser Fakri

AU - Sergeevna, Sergushina Elena

AU - Karampoor, Sajad

AU - Mirzaei, Rasoul

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol. 25-HC is a crucial component in various biological activities, including cholesterol metabolism. In recent years, growing evidence has shown that 25-HC performs a critical function in the etiology of cancer, infectious diseases and autoimmune disorders. This review will summarize the latest findings regarding 25-HC, including its biogenesis, immunomodulatory properties and role in innate/adaptive immunity, inflammation and the development of various types of cancer.

AB - Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol. 25-HC is a crucial component in various biological activities, including cholesterol metabolism. In recent years, growing evidence has shown that 25-HC performs a critical function in the etiology of cancer, infectious diseases and autoimmune disorders. This review will summarize the latest findings regarding 25-HC, including its biogenesis, immunomodulatory properties and role in innate/adaptive immunity, inflammation and the development of various types of cancer.

KW - 25-HC

KW - cancer

KW - immunity

KW - immunometabolism

KW - inflammation

UR - http://www.scopus.com/inward/record.url?scp=85150751592&partnerID=8YFLogxK

U2 - 10.2217/fon-2022-0819

DO - 10.2217/fon-2022-0819

M3 - Review article

C2 - 36651359

AN - SCOPUS:85150751592

SN - 1479-6694

VL - 18

SP - 4415

EP - 4442

JO - Future Oncology

JF - Future Oncology

IS - 39

ER -

Pathogenic role of 25-hydroxycholesterol in cancer development and progression

Abstract

Keywords

UN SDGs

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