TY - JOUR
T1 - Overview of the role and action mechanism of microRNA-128 in viral infections
AU - Alshahrani, Shadia Hamoud
AU - Alameri, Ameer A.
AU - Kahar, Fitriani
AU - Alexis Ramírez-Coronel, Andrés
AU - Fadhel Obaid, Rasha
AU - Alsaikhan, Fahad
AU - Zabibah, Rahman S.
AU - Qasim, Qutaiba A.
AU - Altalbawy, Farag M.A.
AU - Fakri Mustafa, Yasser
AU - Mirzaei, Rasoul
AU - Karampoor, Sajad
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/3
Y1 - 2023/3
N2 - Recently in vivo and in vitro studies have provided evidence establishing the significance of microRNAs (miRNAs) in both physiological and pathological conditions. In this regard, the role of miRNA-128 (miR-128) in health and diseases has been found, and its critical regulatory role in the context of some viral diseases has been recently identified. For instance, it has been found that miR-128 can serve as an antiviral mediator and significantly limit the replication and dissemination of human immunodeficiency virus type 1 (HIV-1). Besides, it has been noted that poliovirus receptor-related 4 (PVRL4) is post-transcriptionally regulated by miR-128, representing possible miRNA targets that can modulate measles virus infection. Of note, the downregulation of seminal exosomes eca-miR-128 is associated with the long-term persistence of Equine arteritis virus (EAV) in the reproductive tract, and this particular miRNA is a putative regulator of chemokine ligand 16 (C-X-C motif) as determined by target prediction analysis. In this review, the latest information on the role and action mechanism of miR-128 in viral infections will be summarized and discussed in detail.
AB - Recently in vivo and in vitro studies have provided evidence establishing the significance of microRNAs (miRNAs) in both physiological and pathological conditions. In this regard, the role of miRNA-128 (miR-128) in health and diseases has been found, and its critical regulatory role in the context of some viral diseases has been recently identified. For instance, it has been found that miR-128 can serve as an antiviral mediator and significantly limit the replication and dissemination of human immunodeficiency virus type 1 (HIV-1). Besides, it has been noted that poliovirus receptor-related 4 (PVRL4) is post-transcriptionally regulated by miR-128, representing possible miRNA targets that can modulate measles virus infection. Of note, the downregulation of seminal exosomes eca-miR-128 is associated with the long-term persistence of Equine arteritis virus (EAV) in the reproductive tract, and this particular miRNA is a putative regulator of chemokine ligand 16 (C-X-C motif) as determined by target prediction analysis. In this review, the latest information on the role and action mechanism of miR-128 in viral infections will be summarized and discussed in detail.
KW - Equine arteritis virus
KW - Hepatitis C virus
KW - Herpesvirus of Turkey
KW - Human immunodeficiency virus type 1
KW - Inflammation
KW - Marek's disease
KW - Measles virus
KW - miR-128
UR - http://www.scopus.com/inward/record.url?scp=85147557129&partnerID=8YFLogxK
U2 - 10.1016/j.micpath.2023.106020
DO - 10.1016/j.micpath.2023.106020
M3 - Review article
C2 - 36746316
AN - SCOPUS:85147557129
SN - 0882-4010
VL - 176
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
M1 - 106020
ER -
