Organoid Models of Heart Diseases: Find a New Channel in Improvements of Cardiac Regenerative Medicine

Saade Abdalkareem Jasim; Dmitry Olegovich Bokov; Wanich Suksatan; Fahad Alsaikhan; Mohammed Abed Jawad; Satish Kumar Sharma; Supat Chupradit; Lakshmi Thangavelu

doi:10.2174/0929867330666221021122603

Organoid Models of Heart Diseases: Find a New Channel in Improvements of Cardiac Regenerative Medicine

Saade Abdalkareem Jasim
, Dmitry Olegovich Bokov
, Wanich Suksatan
, Fahad Alsaikhan
, Mohammed Abed Jawad
, Satish Kumar Sharma
, Supat Chupradit
, Lakshmi Thangavelu

Clinical Pharmacy

Al-Maarif University College
Sechenov First Moscow State Medical University
Biotechnology and Food Safety
Chulabhorn Royal Academy
Al-Nisour University College
Glocal University
Chiang Mai University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

We are experiencing a revolution in regenerative medicine. Recent developments in organoid technology have provided unique opportunities for studying human biology and diseases. Indeed, organoid models have revolutionized the in vitro culture tools for biomedical research by creating robust three-dimensional (3D) architecture to re-capitulate the primary tissues' cellular heterogeneity, structure, and functions. Such organoid technology enables researchers to re-create human organs and diseases model in a culture dish. It thus holds excellent promises for many translational applications such as regenerative medicine, drug discovery, and precision medicine. This review sum-marizes the current knowledge on the progression and promotion of organoid models, particularly with the heart disease approach. We discuss the usefulness of clinical applications of cardiac organoids and ultimately highlight the currently advanced therapeutic strategies in vitro model of organoids aimed at personalizing heart disease treatment.

Original language	English
Pages (from-to)	3726-3742
Number of pages	17
Journal	Current Medicinal Chemistry
Volume	30
Issue number	33
DOIs	https://doi.org/10.2174/0929867330666221021122603
State	Published - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cardiac organoid
drug discovery
heart diseases
organoid technology
personalizing heart disease treatment
regenerative medicine

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10.2174/0929867330666221021122603

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@article{dc3fbf0036994b21a3571e631e1e787d,

title = "Organoid Models of Heart Diseases: Find a New Channel in Improvements of Cardiac Regenerative Medicine",

abstract = "We are experiencing a revolution in regenerative medicine. Recent developments in organoid technology have provided unique opportunities for studying human biology and diseases. Indeed, organoid models have revolutionized the in vitro culture tools for biomedical research by creating robust three-dimensional (3D) architecture to re-capitulate the primary tissues' cellular heterogeneity, structure, and functions. Such organoid technology enables researchers to re-create human organs and diseases model in a culture dish. It thus holds excellent promises for many translational applications such as regenerative medicine, drug discovery, and precision medicine. This review sum-marizes the current knowledge on the progression and promotion of organoid models, particularly with the heart disease approach. We discuss the usefulness of clinical applications of cardiac organoids and ultimately highlight the currently advanced therapeutic strategies in vitro model of organoids aimed at personalizing heart disease treatment.",

keywords = "Cardiac organoid, drug discovery, heart diseases, organoid technology, personalizing heart disease treatment, regenerative medicine",

author = "Jasim, \{Saade Abdalkareem\} and Bokov, \{Dmitry Olegovich\} and Wanich Suksatan and Fahad Alsaikhan and Jawad, \{Mohammed Abed\} and Sharma, \{Satish Kumar\} and Supat Chupradit and Lakshmi Thangavelu",

note = "Publisher Copyright: {\textcopyright} 2023 Bentham Science Publishers.",

year = "2023",

doi = "10.2174/0929867330666221021122603",

language = "English",

volume = "30",

pages = "3726--3742",

journal = "Current Medicinal Chemistry",

issn = "0929-8673",

publisher = "Bentham Science Publishers",

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TY - JOUR

T1 - Organoid Models of Heart Diseases

T2 - Find a New Channel in Improvements of Cardiac Regenerative Medicine

AU - Jasim, Saade Abdalkareem

AU - Bokov, Dmitry Olegovich

AU - Suksatan, Wanich

AU - Alsaikhan, Fahad

AU - Jawad, Mohammed Abed

AU - Sharma, Satish Kumar

AU - Chupradit, Supat

AU - Thangavelu, Lakshmi

PY - 2023

Y1 - 2023

N2 - We are experiencing a revolution in regenerative medicine. Recent developments in organoid technology have provided unique opportunities for studying human biology and diseases. Indeed, organoid models have revolutionized the in vitro culture tools for biomedical research by creating robust three-dimensional (3D) architecture to re-capitulate the primary tissues' cellular heterogeneity, structure, and functions. Such organoid technology enables researchers to re-create human organs and diseases model in a culture dish. It thus holds excellent promises for many translational applications such as regenerative medicine, drug discovery, and precision medicine. This review sum-marizes the current knowledge on the progression and promotion of organoid models, particularly with the heart disease approach. We discuss the usefulness of clinical applications of cardiac organoids and ultimately highlight the currently advanced therapeutic strategies in vitro model of organoids aimed at personalizing heart disease treatment.

AB - We are experiencing a revolution in regenerative medicine. Recent developments in organoid technology have provided unique opportunities for studying human biology and diseases. Indeed, organoid models have revolutionized the in vitro culture tools for biomedical research by creating robust three-dimensional (3D) architecture to re-capitulate the primary tissues' cellular heterogeneity, structure, and functions. Such organoid technology enables researchers to re-create human organs and diseases model in a culture dish. It thus holds excellent promises for many translational applications such as regenerative medicine, drug discovery, and precision medicine. This review sum-marizes the current knowledge on the progression and promotion of organoid models, particularly with the heart disease approach. We discuss the usefulness of clinical applications of cardiac organoids and ultimately highlight the currently advanced therapeutic strategies in vitro model of organoids aimed at personalizing heart disease treatment.

KW - Cardiac organoid

KW - drug discovery

KW - heart diseases

KW - organoid technology

KW - personalizing heart disease treatment

KW - regenerative medicine

UR - https://www.scopus.com/pages/publications/85159735998

U2 - 10.2174/0929867330666221021122603

DO - 10.2174/0929867330666221021122603

M3 - Review article

C2 - 36281859

AN - SCOPUS:85159735998

SN - 0929-8673

VL - 30

SP - 3726

EP - 3742

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 33

ER -

Organoid Models of Heart Diseases: Find a New Channel in Improvements of Cardiac Regenerative Medicine

Abstract

UN SDGs

Keywords

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