TY - JOUR
T1 - Organoid Models of Heart Diseases
T2 - Find a New Channel in Improvements of Cardiac Regenerative Medicine
AU - Jasim, Saade Abdalkareem
AU - Bokov, Dmitry Olegovich
AU - Suksatan, Wanich
AU - Alsaikhan, Fahad
AU - Jawad, Mohammed Abed
AU - Sharma, Satish Kumar
AU - Chupradit, Supat
AU - Thangavelu, Lakshmi
N1 - Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023
Y1 - 2023
N2 - We are experiencing a revolution in regenerative medicine. Recent developments in organoid technology have provided unique opportunities for studying human biology and diseases. Indeed, organoid models have revolutionized the in vitro culture tools for biomedical research by creating robust three-dimensional (3D) architecture to re-capitulate the primary tissues' cellular heterogeneity, structure, and functions. Such organoid technology enables researchers to re-create human organs and diseases model in a culture dish. It thus holds excellent promises for many translational applications such as regenerative medicine, drug discovery, and precision medicine. This review sum-marizes the current knowledge on the progression and promotion of organoid models, particularly with the heart disease approach. We discuss the usefulness of clinical applications of cardiac organoids and ultimately highlight the currently advanced therapeutic strategies in vitro model of organoids aimed at personalizing heart disease treatment.
AB - We are experiencing a revolution in regenerative medicine. Recent developments in organoid technology have provided unique opportunities for studying human biology and diseases. Indeed, organoid models have revolutionized the in vitro culture tools for biomedical research by creating robust three-dimensional (3D) architecture to re-capitulate the primary tissues' cellular heterogeneity, structure, and functions. Such organoid technology enables researchers to re-create human organs and diseases model in a culture dish. It thus holds excellent promises for many translational applications such as regenerative medicine, drug discovery, and precision medicine. This review sum-marizes the current knowledge on the progression and promotion of organoid models, particularly with the heart disease approach. We discuss the usefulness of clinical applications of cardiac organoids and ultimately highlight the currently advanced therapeutic strategies in vitro model of organoids aimed at personalizing heart disease treatment.
KW - Cardiac organoid
KW - drug discovery
KW - heart diseases
KW - organoid technology
KW - personalizing heart disease treatment
KW - regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85159735998&partnerID=8YFLogxK
U2 - 10.2174/0929867330666221021122603
DO - 10.2174/0929867330666221021122603
M3 - Review article
C2 - 36281859
AN - SCOPUS:85159735998
SN - 0929-8673
VL - 30
SP - 3726
EP - 3742
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 33
ER -
