Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development

Sandra Kannampuzha; Abilash Valsala Gopalakrishnan; Hafiza Padinharayil; Reema Rose Alappat; Kavya V. Anilkumar; Alex George; Abhijit Dey; Balachandar Vellingiri; Harishkumar Madhyastha; Raja Ganesan; Thiyagarajan Ramesh; Rama Jayaraj; D. S. Prabakaran

doi:10.3390/pathogens12060770

Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development

Sandra Kannampuzha, Abilash Valsala Gopalakrishnan, Hafiza Padinharayil, Reema Rose Alappat, Kavya V. Anilkumar, Alex George, Abhijit Dey, Balachandar Vellingiri, Harishkumar Madhyastha, Raja Ganesan, Thiyagarajan Ramesh, Rama Jayaraj, D. S. Prabakaran

Basic Medical Sciences

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Infection with viruses, bacteria, and parasites are thought to be the underlying cause of about 8–17% of the world’s cancer burden, i.e., approximately one in every five malignancies globally is caused by an infectious pathogen. Oncogenesis is thought to be aided by eleven major pathogens. It is crucial to identify microorganisms that potentially act as human carcinogens and to understand how exposure to such pathogens occur as well as the following carcinogenic pathways they induce. Gaining knowledge in this field will give important suggestions for effective pathogen-driven cancer care, control, and, ultimately, prevention. This review will mainly focus on the major onco-pathogens and the types of cancer caused by them. It will also discuss the major pathways which, when altered, lead to the progression of these cancers.

Original language	English
Article number	770
Journal	Pathogens
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/pathogens12060770
State	Published - Jun 2023

Keywords

bacteria
cancer
infections
pathogens
viruses

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pathogens12060770

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Kannampuzha, S., Gopalakrishnan, A. V., Padinharayil, H., Alappat, R. R., Anilkumar, K. V., George, A., Dey, A., Vellingiri, B., Madhyastha, H., Ganesan, R., Ramesh, T., Jayaraj, R., & Prabakaran, D. S. (2023). Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development. Pathogens, 12(6), Article 770. https://doi.org/10.3390/pathogens12060770

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title = "Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development",

abstract = "Infection with viruses, bacteria, and parasites are thought to be the underlying cause of about 8–17\% of the world{\textquoteright}s cancer burden, i.e., approximately one in every five malignancies globally is caused by an infectious pathogen. Oncogenesis is thought to be aided by eleven major pathogens. It is crucial to identify microorganisms that potentially act as human carcinogens and to understand how exposure to such pathogens occur as well as the following carcinogenic pathways they induce. Gaining knowledge in this field will give important suggestions for effective pathogen-driven cancer care, control, and, ultimately, prevention. This review will mainly focus on the major onco-pathogens and the types of cancer caused by them. It will also discuss the major pathways which, when altered, lead to the progression of these cancers.",

keywords = "bacteria, cancer, infections, pathogens, viruses",

author = "Sandra Kannampuzha and Gopalakrishnan, \{Abilash Valsala\} and Hafiza Padinharayil and Alappat, \{Reema Rose\} and Anilkumar, \{Kavya V.\} and Alex George and Abhijit Dey and Balachandar Vellingiri and Harishkumar Madhyastha and Raja Ganesan and Thiyagarajan Ramesh and Rama Jayaraj and Prabakaran, \{D. S.\}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jun,

doi = "10.3390/pathogens12060770",

language = "English",

volume = "12",

journal = "Pathogens",

issn = "2076-0817",

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T1 - Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development

AU - Kannampuzha, Sandra

AU - Gopalakrishnan, Abilash Valsala

AU - Padinharayil, Hafiza

AU - Alappat, Reema Rose

AU - Anilkumar, Kavya V.

AU - George, Alex

AU - Dey, Abhijit

AU - Vellingiri, Balachandar

AU - Madhyastha, Harishkumar

AU - Ganesan, Raja

AU - Ramesh, Thiyagarajan

AU - Jayaraj, Rama

AU - Prabakaran, D. S.

PY - 2023/6

Y1 - 2023/6

N2 - Infection with viruses, bacteria, and parasites are thought to be the underlying cause of about 8–17% of the world’s cancer burden, i.e., approximately one in every five malignancies globally is caused by an infectious pathogen. Oncogenesis is thought to be aided by eleven major pathogens. It is crucial to identify microorganisms that potentially act as human carcinogens and to understand how exposure to such pathogens occur as well as the following carcinogenic pathways they induce. Gaining knowledge in this field will give important suggestions for effective pathogen-driven cancer care, control, and, ultimately, prevention. This review will mainly focus on the major onco-pathogens and the types of cancer caused by them. It will also discuss the major pathways which, when altered, lead to the progression of these cancers.

AB - Infection with viruses, bacteria, and parasites are thought to be the underlying cause of about 8–17% of the world’s cancer burden, i.e., approximately one in every five malignancies globally is caused by an infectious pathogen. Oncogenesis is thought to be aided by eleven major pathogens. It is crucial to identify microorganisms that potentially act as human carcinogens and to understand how exposure to such pathogens occur as well as the following carcinogenic pathways they induce. Gaining knowledge in this field will give important suggestions for effective pathogen-driven cancer care, control, and, ultimately, prevention. This review will mainly focus on the major onco-pathogens and the types of cancer caused by them. It will also discuss the major pathways which, when altered, lead to the progression of these cancers.

KW - bacteria

KW - cancer

KW - infections

KW - pathogens

KW - viruses

UR - http://www.scopus.com/inward/record.url?scp=85163569353&partnerID=8YFLogxK

U2 - 10.3390/pathogens12060770

DO - 10.3390/pathogens12060770

M3 - Review article

AN - SCOPUS:85163569353

SN - 2076-0817

VL - 12

JO - Pathogens

JF - Pathogens

IS - 6

M1 - 770

ER -

Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development

Abstract

Keywords

UN SDGs

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