Novel series of dihydroquinolindihydro-spiro[indoline-3,6’-[1,3]thiazine]-5′-carbonitrile derivatives

Asmaa H. Mohamed; Mohammed B. Alshammari; Esmaat M. El-Sheref; Ashraf A. Aly

doi:10.1016/j.molstruc.2020.128618

Novel series of dihydroquinolindihydro-spiro[indoline-3,6’-[1,3]thiazine]-5′-carbonitrile derivatives

Asmaa H. Mohamed
, Mohammed B. Alshammari
, Esmaat M. El-Sheref
, Ashraf A. Aly

Chemistry

Minia University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A series of new spiro[indoline-3,6’-[1,3]thiazines] were synthesized in modest yields by refluxing of substituted (1,2-dihydroquinolin-3-yl)-methylene)hydrazinecarbothioamides with 2-(2-oxoindolin-3-ylidene)malononitrile in pyridine as a solvent. The structure assignment of all obtained products has been confirmed by ¹H, ¹³C NMR, 2D-NMR, ¹⁵N NMR spectroscopy in addition to elemental analyses. The possible mechanism for the reaction is also discussed.

Original language	English
Article number	128618
Journal	Journal of Molecular Structure
Volume	1219
DOIs	https://doi.org/10.1016/j.molstruc.2020.128618
State	Published - 5 Nov 2020

Keywords

2-(Oxoindolinylidene)malononitrile
Spiro[indoline-3,6'[1,3]thiazine
Thiosemicarbazones

Access to Document

10.1016/j.molstruc.2020.128618

Cite this

@article{0f78b6cf2ac845f79a64855652bf18ae,

title = "Novel series of dihydroquinolindihydro-spiro[indoline-3,6{\textquoteright}-[1,3]thiazine]-5′-carbonitrile derivatives",

abstract = "A series of new spiro[indoline-3,6{\textquoteright}-[1,3]thiazines] were synthesized in modest yields by refluxing of substituted (1,2-dihydroquinolin-3-yl)-methylene)hydrazinecarbothioamides with 2-(2-oxoindolin-3-ylidene)malononitrile in pyridine as a solvent. The structure assignment of all obtained products has been confirmed by 1H, 13C NMR, 2D-NMR, 15N NMR spectroscopy in addition to elemental analyses. The possible mechanism for the reaction is also discussed.",

keywords = "2-(Oxoindolinylidene)malononitrile, Spiro[indoline-3,6'[1,3]thiazine, Thiosemicarbazones",

author = "Mohamed, \{Asmaa H.\} and Alshammari, \{Mohammed B.\} and El-Sheref, \{Esmaat M.\} and Aly, \{Ashraf A.\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = nov,

day = "5",

doi = "10.1016/j.molstruc.2020.128618",

language = "English",

volume = "1219",

journal = "Journal of Molecular Structure",

issn = "0022-2860",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Novel series of dihydroquinolindihydro-spiro[indoline-3,6’-[1,3]thiazine]-5′-carbonitrile derivatives

AU - Mohamed, Asmaa H.

AU - Alshammari, Mohammed B.

AU - El-Sheref, Esmaat M.

AU - Aly, Ashraf A.

PY - 2020/11/5

Y1 - 2020/11/5

N2 - A series of new spiro[indoline-3,6’-[1,3]thiazines] were synthesized in modest yields by refluxing of substituted (1,2-dihydroquinolin-3-yl)-methylene)hydrazinecarbothioamides with 2-(2-oxoindolin-3-ylidene)malononitrile in pyridine as a solvent. The structure assignment of all obtained products has been confirmed by 1H, 13C NMR, 2D-NMR, 15N NMR spectroscopy in addition to elemental analyses. The possible mechanism for the reaction is also discussed.

AB - A series of new spiro[indoline-3,6’-[1,3]thiazines] were synthesized in modest yields by refluxing of substituted (1,2-dihydroquinolin-3-yl)-methylene)hydrazinecarbothioamides with 2-(2-oxoindolin-3-ylidene)malononitrile in pyridine as a solvent. The structure assignment of all obtained products has been confirmed by 1H, 13C NMR, 2D-NMR, 15N NMR spectroscopy in addition to elemental analyses. The possible mechanism for the reaction is also discussed.

KW - 2-(Oxoindolinylidene)malononitrile

KW - Spiro[indoline-3,6'[1,3]thiazine

KW - Thiosemicarbazones

UR - https://www.scopus.com/pages/publications/85086438223

U2 - 10.1016/j.molstruc.2020.128618

DO - 10.1016/j.molstruc.2020.128618

M3 - Article

AN - SCOPUS:85086438223

SN - 0022-2860

VL - 1219

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 128618

ER -

Novel series of dihydroquinolindihydro-spiro[indoline-3,6’-[1,3]thiazine]-5′-carbonitrile derivatives

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this