TY - JOUR
T1 - Neuropharmacological effect of risperidone
T2 - From chemistry to medicine
AU - Bhat, Asif Ahmad
AU - Gupta, Gaurav
AU - Afzal, Obaid
AU - Kazmi, Imran
AU - Al-Abbasi, Fahad A.
AU - Saleh Altamimi, Abdulmalik
AU - Almalki, Waleed Hassan
AU - Alzarea, Sami I.
AU - Singh, Sachin Kumar
AU - Dua, Kamal
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/1/5
Y1 - 2023/1/5
N2 - As the second-oldest atypical antipsychotic, risperidone has a long history of off-label usage for treating behavioural and psychological signs and symptoms of dementia (BPSD), such as agitation, aggressiveness, and psychosis. Risperidone has been shown in several trials to have a statistically significant benefit when used in a therapeutic context. Several lines of evidence suggest a possible role of risperidone via the antagonistic effect of Dopamine D2 and 5HT-receptor in different neurological diseases like cognitive dysfunction of schizophrenia, neuroinflammation, Huntington's disease, and sleep cycle management. Therefore, the pharmacological interactions of risperidone in all these diseases were investigated. Some reports on the use of risperidone in the treatment of dopaminergic psychosis have been slightly conflicting. However, more research is needed to evaluate the role of risperidone in the treatment of these neurological diseases.
AB - As the second-oldest atypical antipsychotic, risperidone has a long history of off-label usage for treating behavioural and psychological signs and symptoms of dementia (BPSD), such as agitation, aggressiveness, and psychosis. Risperidone has been shown in several trials to have a statistically significant benefit when used in a therapeutic context. Several lines of evidence suggest a possible role of risperidone via the antagonistic effect of Dopamine D2 and 5HT-receptor in different neurological diseases like cognitive dysfunction of schizophrenia, neuroinflammation, Huntington's disease, and sleep cycle management. Therefore, the pharmacological interactions of risperidone in all these diseases were investigated. Some reports on the use of risperidone in the treatment of dopaminergic psychosis have been slightly conflicting. However, more research is needed to evaluate the role of risperidone in the treatment of these neurological diseases.
KW - Dopaminergic psychosis
KW - Neuroinflammation
KW - Neurological diseases
KW - Neuropharmacological treatment
KW - Risperidone
UR - http://www.scopus.com/inward/record.url?scp=85143796024&partnerID=8YFLogxK
U2 - 10.1016/j.cbi.2022.110296
DO - 10.1016/j.cbi.2022.110296
M3 - Review article
C2 - 36496108
AN - SCOPUS:85143796024
SN - 0009-2797
VL - 369
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
M1 - 110296
ER -