Molluscicidal activity of cardiac glycosides isolated from Adenium obesum

Ali A. Alzabib; Yasser Abobakr; Ali S. Al-Sarar; Hamdy I. Hussein; Omer A. Basudan; Ali A. El-Gamal; Maged S. Abdel-Kader; Mahmoud H. El_Komy

doi:10.1002/ps.5388

Molluscicidal activity of cardiac glycosides isolated from Adenium obesum

Ali A. Alzabib, Yasser Abobakr, Ali S. Al-Sarar, Hamdy I. Hussein, Omer A. Basudan, Ali A. El-Gamal, Maged S. Abdel-Kader, Mahmoud H. El_Komy

Fharmacognosy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

BACKGROUND: Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum. RESULTS: The benzene-soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD₅₀) of 4.91 µg g⁻¹ body weight (bw). The bioactivity-guided chemical exploration of the benzene-soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD₅₀ values of 5.39 and 4.3 µg g⁻¹ bw, respectively. CONCLUSION: Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time.

Original language	English
Pages (from-to)	2770-2775
Number of pages	6
Journal	Pest Management Science
Volume	75
Issue number	10
DOIs	https://doi.org/10.1002/ps.5388
State	Published - 1 Oct 2019

Keywords

Adenium obesum
cardiac glycosides
cerberin
molluscicidal activity
neriifolin

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title = "Molluscicidal activity of cardiac glycosides isolated from Adenium obesum",

abstract = "BACKGROUND: Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum. RESULTS: The benzene-soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 µg g−1 body weight (bw). The bioactivity-guided chemical exploration of the benzene-soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 µg g−1 bw, respectively. CONCLUSION: Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time.",

keywords = "Adenium obesum, cardiac glycosides, cerberin, molluscicidal activity, neriifolin",

author = "Alzabib, \{Ali A.\} and Yasser Abobakr and Al-Sarar, \{Ali S.\} and Hussein, \{Hamdy I.\} and Basudan, \{Omer A.\} and El-Gamal, \{Ali A.\} and Abdel-Kader, \{Maged S.\} and El\_Komy, \{Mahmoud H.\}",

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year = "2019",

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doi = "10.1002/ps.5388",

language = "English",

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T1 - Molluscicidal activity of cardiac glycosides isolated from Adenium obesum

AU - Alzabib, Ali A.

AU - Abobakr, Yasser

AU - Al-Sarar, Ali S.

AU - Hussein, Hamdy I.

AU - Basudan, Omer A.

AU - El-Gamal, Ali A.

AU - Abdel-Kader, Maged S.

AU - El_Komy, Mahmoud H.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - BACKGROUND: Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum. RESULTS: The benzene-soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 µg g−1 body weight (bw). The bioactivity-guided chemical exploration of the benzene-soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 µg g−1 bw, respectively. CONCLUSION: Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time.

AB - BACKGROUND: Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum. RESULTS: The benzene-soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 µg g−1 body weight (bw). The bioactivity-guided chemical exploration of the benzene-soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 µg g−1 bw, respectively. CONCLUSION: Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time.

KW - Adenium obesum

KW - cardiac glycosides

KW - cerberin

KW - molluscicidal activity

KW - neriifolin

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DO - 10.1002/ps.5388

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SP - 2770

EP - 2775

JO - Pest Management Science

JF - Pest Management Science

IS - 10

ER -

Molluscicidal activity of cardiac glycosides isolated from Adenium obesum

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Keywords

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