Middle East respiratory syndrome: Pathogenesis and therapeutic developments

Hani Choudhry; Muhammed A. Bakhrebah; Wesam H. Abdulaal; Mazin A. Zamzami; Othman A. Baothman; Mohammed A. Hassan; Mustafa Zeyadi; Nawal Helmi; Faisal Alzahrani; Ashraf Ali; Mohammad Khalid Zakaria; Mohammad Azhar Kamal; Mohiuddin Khan Warsi; Firoz Ahmed; Mahmood Rasool; Mohammad Sarwar Jamal

doi:10.2217/fvl-2018-0201

Middle East respiratory syndrome: Pathogenesis and therapeutic developments

Hani Choudhry, Muhammed A. Bakhrebah, Wesam H. Abdulaal, Mazin A. Zamzami, Othman A. Baothman, Mohammed A. Hassan, Mustafa Zeyadi, Nawal Helmi, Faisal Alzahrani, Ashraf Ali, Mohammad Khalid Zakaria, Mohammad Azhar Kamal, Mohiuddin Khan Warsi, Firoz Ahmed, Mahmood Rasool, Mohammad Sarwar Jamal

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.

Original language	English
Pages (from-to)	237-246
Number of pages	10
Journal	Future Virology
Volume	14
Issue number	4
DOIs	https://doi.org/10.2217/fvl-2018-0201
State	Published - Apr 2019
Externally published	Yes

Keywords

Arabian Peninsula
coronavirus
global
macrophages
MERS
SARS
Saudi Arabia
therapeutic
vaccine
WHO

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Choudhry, H., Bakhrebah, M. A., Abdulaal, W. H., Zamzami, M. A., Baothman, O. A., Hassan, M. A., Zeyadi, M., Helmi, N., Alzahrani, F., Ali, A., Zakaria, M. K., Kamal, M. A., Warsi, M. K., Ahmed, F., Rasool, M., & Jamal, M. S. (2019). Middle East respiratory syndrome: Pathogenesis and therapeutic developments. Future Virology, 14(4), 237-246. https://doi.org/10.2217/fvl-2018-0201

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title = "Middle East respiratory syndrome: Pathogenesis and therapeutic developments",

abstract = "The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.",

keywords = "Arabian Peninsula, coronavirus, global, macrophages, MERS, SARS, Saudi Arabia, therapeutic, vaccine, WHO",

author = "Hani Choudhry and Bakhrebah, \{Muhammed A.\} and Abdulaal, \{Wesam H.\} and Zamzami, \{Mazin A.\} and Baothman, \{Othman A.\} and Hassan, \{Mohammed A.\} and Mustafa Zeyadi and Nawal Helmi and Faisal Alzahrani and Ashraf Ali and Zakaria, \{Mohammad Khalid\} and Kamal, \{Mohammad Azhar\} and Warsi, \{Mohiuddin Khan\} and Firoz Ahmed and Mahmood Rasool and Jamal, \{Mohammad Sarwar\}",

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year = "2019",

month = apr,

doi = "10.2217/fvl-2018-0201",

language = "English",

volume = "14",

pages = "237--246",

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AU - Bakhrebah, Muhammed A.

AU - Abdulaal, Wesam H.

AU - Zamzami, Mazin A.

AU - Baothman, Othman A.

AU - Hassan, Mohammed A.

AU - Zeyadi, Mustafa

AU - Helmi, Nawal

AU - Alzahrani, Faisal

AU - Ali, Ashraf

AU - Zakaria, Mohammad Khalid

AU - Kamal, Mohammad Azhar

AU - Warsi, Mohiuddin Khan

AU - Ahmed, Firoz

AU - Rasool, Mahmood

AU - Jamal, Mohammad Sarwar

PY - 2019/4

Y1 - 2019/4

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AB - The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.

KW - Arabian Peninsula

KW - coronavirus

KW - global

KW - macrophages

KW - MERS

KW - SARS

KW - Saudi Arabia

KW - therapeutic

KW - vaccine

KW - WHO

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DO - 10.2217/fvl-2018-0201

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VL - 14

SP - 237

EP - 246

JO - Future Virology

JF - Future Virology

IS - 4

ER -

Middle East respiratory syndrome: Pathogenesis and therapeutic developments

Abstract

Keywords

UN SDGs

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