TY - JOUR
T1 - Metal complexes of N(4)-substituted analogues of the antiviral drug methisazone {1-methylisatin thiosemicarbazone}
AU - West, Douglas X.
AU - El-Sawaf, Ayman K.
AU - Bain, Gordon A.
PY - 1997
Y1 - 1997
N2 - 1-Methylisatin N(4)-methyl- and N(4)-dimethylthiosemicarbazone, HMIs4M and HMIs4DM, respectively, and their cobalt(II), nickel(II) and copper(II) complexes have been prepared and characterized, by elemental analyses, molar conductivities, magnetic susceptibilities and by spectral methods: i.r., u.v.-vis.-n.i.r., n.m.r. and e.s.r. The two thiosemicarbazones, upon loss of the N(2)H, coordinate as monoanions via the azomethine nitrogen and thiolato sulfur atoms, as well as the isatin oxygen {i.e. except for [Cu(MIs4M)2] and [Cu(MIs4DM)2]} to give complexes of the general formula [M(MIs)2] and [M(MIs)Cl] where M = CoII, NiII and CuII and MIs = both HMIs4M and HMIs4DM. The preparation with HMIs4DM and nickel(II) chloride formed [Ni(MIs4DM)2] rather than [Ni(MIs4DM)Cl]. Copper(II) bromide yielded complexes with low magnetic susceptibilities, which are considered to be binuclear {i.e. [Cu(MIs4M)Br]2 and [Cu(MIs4DM)Br]2}.
AB - 1-Methylisatin N(4)-methyl- and N(4)-dimethylthiosemicarbazone, HMIs4M and HMIs4DM, respectively, and their cobalt(II), nickel(II) and copper(II) complexes have been prepared and characterized, by elemental analyses, molar conductivities, magnetic susceptibilities and by spectral methods: i.r., u.v.-vis.-n.i.r., n.m.r. and e.s.r. The two thiosemicarbazones, upon loss of the N(2)H, coordinate as monoanions via the azomethine nitrogen and thiolato sulfur atoms, as well as the isatin oxygen {i.e. except for [Cu(MIs4M)2] and [Cu(MIs4DM)2]} to give complexes of the general formula [M(MIs)2] and [M(MIs)Cl] where M = CoII, NiII and CuII and MIs = both HMIs4M and HMIs4DM. The preparation with HMIs4DM and nickel(II) chloride formed [Ni(MIs4DM)2] rather than [Ni(MIs4DM)Cl]. Copper(II) bromide yielded complexes with low magnetic susceptibilities, which are considered to be binuclear {i.e. [Cu(MIs4M)Br]2 and [Cu(MIs4DM)Br]2}.
UR - http://www.scopus.com/inward/record.url?scp=2342464900&partnerID=8YFLogxK
U2 - 10.1023/A:1006901328527
DO - 10.1023/A:1006901328527
M3 - Article
AN - SCOPUS:2342464900
SN - 0340-4285
VL - 23
SP - 1
EP - 6
JO - Transition Metal Chemistry
JF - Transition Metal Chemistry
IS - 1
ER -