TY - JOUR
T1 - Medicinal and chemosensing applications of chitosan based material
T2 - A review
AU - Al-Ahmary, Khairia Mohammed
AU - Al-Mhyawi, Saedah R.
AU - Khan, Sikandar
AU - Alrashdi, Kamelah S.
AU - Shafie, Alaa
AU - Babalghith, Ahmad O.
AU - Ashour, Amal Adnan
AU - Alshareef, Tasneem H.
AU - Moglad, Ehssan
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/5
Y1 - 2024/5
N2 - Chitosan (CTS), has emerged as a highly intriguing biopolymer with widespread applications, drawing significant attention in various fields ranging from medicinal to chemosensing. Key characteristics of chitosan include solubility, biocompatibility, biodegradability and reactivity, making it versatile in numerous sectors. Several derivatives have been documented for their diverse therapeutic properties, such as antibacterial, antifungal, anti-diabetic, anti-inflammatory, anticancer and antioxidant activities. Furthermore, these compounds serve as highly sensitive and selective chemosensor for the detection of various analytes such as heavy metal ions, anions and various other species in agricultural, environmental and biological matrixes. CTS derivatives interacting with these species and give analytical signals. In this review, we embark on an exploration of the latest advancements in CTS-based materials, emphasizing their noteworthy contributions to medicinal chemistry spanning the years from 2021 to 2023. The intrinsic biological and physiological properties of CTS make it an ideal platform for designing materials that interact seamlessly with biological systems. The review also explores the utilization of chitosan-based materials for the development of colorimetric and fluorimetric chemosensors capable of detecting metal ions, anions and various other species, contributing to advancements in environmental monitoring, healthcare diagnostics, and industrial processes.
AB - Chitosan (CTS), has emerged as a highly intriguing biopolymer with widespread applications, drawing significant attention in various fields ranging from medicinal to chemosensing. Key characteristics of chitosan include solubility, biocompatibility, biodegradability and reactivity, making it versatile in numerous sectors. Several derivatives have been documented for their diverse therapeutic properties, such as antibacterial, antifungal, anti-diabetic, anti-inflammatory, anticancer and antioxidant activities. Furthermore, these compounds serve as highly sensitive and selective chemosensor for the detection of various analytes such as heavy metal ions, anions and various other species in agricultural, environmental and biological matrixes. CTS derivatives interacting with these species and give analytical signals. In this review, we embark on an exploration of the latest advancements in CTS-based materials, emphasizing their noteworthy contributions to medicinal chemistry spanning the years from 2021 to 2023. The intrinsic biological and physiological properties of CTS make it an ideal platform for designing materials that interact seamlessly with biological systems. The review also explores the utilization of chitosan-based materials for the development of colorimetric and fluorimetric chemosensors capable of detecting metal ions, anions and various other species, contributing to advancements in environmental monitoring, healthcare diagnostics, and industrial processes.
KW - Antibacterial
KW - Anticancer
KW - Biocompatibility
KW - Biomolecules
KW - Chemosensor
UR - http://www.scopus.com/inward/record.url?scp=85190743037&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2024.131493
DO - 10.1016/j.ijbiomac.2024.131493
M3 - Review article
C2 - 38608983
AN - SCOPUS:85190743037
SN - 0141-8130
VL - 268
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 131493
ER -
