Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: Potential bone tissue engineering and antibacterial properties

Hanan A. Albalwi; Mehrez E. El-Naggar; Manal Abou Taleb; Abul Kalam; Noweir Ahmad Alghamdi; Mervat S. Mostafa; Salem Salem; M. Afifi

doi:10.1016/j.jmrt.2022.04.106

Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: Potential bone tissue engineering and antibacterial properties

Hanan A. Albalwi, Mehrez E. El-Naggar, Manal Abou Taleb, Abul Kalam, Noweir Ahmad Alghamdi, Mervat S. Mostafa, Salem Salem, M. Afifi

Chemistry

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The spreading of diseases that cause major bone defects urges the need for fabricating bone substitutes. Hydroxyapatite (HAP)/ytterbium oxide (Yb₂O₃)/graphene oxide (GO) nanocomposite is fabricated and studied for its bioactivity, biocompatibility, microhardness, and antimicrobial activity to be used as bone replacement biomaterial. Moreover, the SEM micrographs revealed the improvement in scaffold porosity and biocompatibility, showing a particle size range from 0.1 to 1.5 μm. HAP/Yb₂O₃/GO shows enhanced roughness parameters in which the roughness average value reached 40.5 nm. Furthermore, the improved osteoblast cells attachment and proliferation obtained by HAP/Yb₂O₃/GO nanocomposite is confirmed via cell viability test the high value of 97.7 ± 2.1%. HAP/Yb₂O₃/GO shows antibacterial properties against Escherichia coli and Staphylococcus aureus that evidenced with inhibition zone 12.5 ± 1 mm and 11.8 ± 1.1 mm, respectively. Besides, HAP/Yb₂O₃/GO showed the highest microhardness values of 3.4 ± 0.2 GPa.

Original language	English
Pages (from-to)	4834-4845
Number of pages	12
Journal	Journal of Materials Research and Technology
Volume	18
DOIs	https://doi.org/10.1016/j.jmrt.2022.04.106
State	Published - May 2022

Keywords

Cell viability
Graphene oxide
Hydroxyapatite
Tissue engineering
YbO

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10.1016/j.jmrt.2022.04.106

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Albalwi, H. A., El-Naggar, M. E., Taleb, M. A., Kalam, A., Alghamdi, N. A., Mostafa, M. S., Salem, S., & Afifi, M. (2022). Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: Potential bone tissue engineering and antibacterial properties. Journal of Materials Research and Technology, 18, 4834-4845. https://doi.org/10.1016/j.jmrt.2022.04.106

@article{16a0f383d521444dbaceeec20703b696,

title = "Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: Potential bone tissue engineering and antibacterial properties",

abstract = "The spreading of diseases that cause major bone defects urges the need for fabricating bone substitutes. Hydroxyapatite (HAP)/ytterbium oxide (Yb2O3)/graphene oxide (GO) nanocomposite is fabricated and studied for its bioactivity, biocompatibility, microhardness, and antimicrobial activity to be used as bone replacement biomaterial. Moreover, the SEM micrographs revealed the improvement in scaffold porosity and biocompatibility, showing a particle size range from 0.1 to 1.5 μm. HAP/Yb2O3/GO shows enhanced roughness parameters in which the roughness average value reached 40.5 nm. Furthermore, the improved osteoblast cells attachment and proliferation obtained by HAP/Yb2O3/GO nanocomposite is confirmed via cell viability test the high value of 97.7 ± 2.1\%. HAP/Yb2O3/GO shows antibacterial properties against Escherichia coli and Staphylococcus aureus that evidenced with inhibition zone 12.5 ± 1 mm and 11.8 ± 1.1 mm, respectively. Besides, HAP/Yb2O3/GO showed the highest microhardness values of 3.4 ± 0.2 GPa.",

keywords = "Cell viability, Graphene oxide, Hydroxyapatite, Tissue engineering, YbO",

author = "Albalwi, \{Hanan A.\} and El-Naggar, \{Mehrez E.\} and Taleb, \{Manal Abou\} and Abul Kalam and Alghamdi, \{Noweir Ahmad\} and Mostafa, \{Mervat S.\} and Salem Salem and M. Afifi",

year = "2022",

month = may,

doi = "10.1016/j.jmrt.2022.04.106",

language = "English",

volume = "18",

pages = "4834--4845",

journal = "Journal of Materials Research and Technology",

issn = "2238-7854",

publisher = "Elsevier Editora Ltda",

}

Albalwi, HA, El-Naggar, ME, Taleb, MA, Kalam, A, Alghamdi, NA, Mostafa, MS, Salem, S & Afifi, M 2022, 'Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: Potential bone tissue engineering and antibacterial properties', Journal of Materials Research and Technology, vol. 18, pp. 4834-4845. https://doi.org/10.1016/j.jmrt.2022.04.106

Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: Potential bone tissue engineering and antibacterial properties. / Albalwi, Hanan A.; El-Naggar, Mehrez E.; Taleb, Manal Abou et al.
In: Journal of Materials Research and Technology, Vol. 18, 05.2022, p. 4834-4845.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide

T2 - Potential bone tissue engineering and antibacterial properties

AU - Albalwi, Hanan A.

AU - El-Naggar, Mehrez E.

AU - Taleb, Manal Abou

AU - Kalam, Abul

AU - Alghamdi, Noweir Ahmad

AU - Mostafa, Mervat S.

AU - Salem, Salem

AU - Afifi, M.

PY - 2022/5

Y1 - 2022/5

N2 - The spreading of diseases that cause major bone defects urges the need for fabricating bone substitutes. Hydroxyapatite (HAP)/ytterbium oxide (Yb2O3)/graphene oxide (GO) nanocomposite is fabricated and studied for its bioactivity, biocompatibility, microhardness, and antimicrobial activity to be used as bone replacement biomaterial. Moreover, the SEM micrographs revealed the improvement in scaffold porosity and biocompatibility, showing a particle size range from 0.1 to 1.5 μm. HAP/Yb2O3/GO shows enhanced roughness parameters in which the roughness average value reached 40.5 nm. Furthermore, the improved osteoblast cells attachment and proliferation obtained by HAP/Yb2O3/GO nanocomposite is confirmed via cell viability test the high value of 97.7 ± 2.1%. HAP/Yb2O3/GO shows antibacterial properties against Escherichia coli and Staphylococcus aureus that evidenced with inhibition zone 12.5 ± 1 mm and 11.8 ± 1.1 mm, respectively. Besides, HAP/Yb2O3/GO showed the highest microhardness values of 3.4 ± 0.2 GPa.

AB - The spreading of diseases that cause major bone defects urges the need for fabricating bone substitutes. Hydroxyapatite (HAP)/ytterbium oxide (Yb2O3)/graphene oxide (GO) nanocomposite is fabricated and studied for its bioactivity, biocompatibility, microhardness, and antimicrobial activity to be used as bone replacement biomaterial. Moreover, the SEM micrographs revealed the improvement in scaffold porosity and biocompatibility, showing a particle size range from 0.1 to 1.5 μm. HAP/Yb2O3/GO shows enhanced roughness parameters in which the roughness average value reached 40.5 nm. Furthermore, the improved osteoblast cells attachment and proliferation obtained by HAP/Yb2O3/GO nanocomposite is confirmed via cell viability test the high value of 97.7 ± 2.1%. HAP/Yb2O3/GO shows antibacterial properties against Escherichia coli and Staphylococcus aureus that evidenced with inhibition zone 12.5 ± 1 mm and 11.8 ± 1.1 mm, respectively. Besides, HAP/Yb2O3/GO showed the highest microhardness values of 3.4 ± 0.2 GPa.

KW - Cell viability

KW - Graphene oxide

KW - Hydroxyapatite

KW - Tissue engineering

KW - YbO

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U2 - 10.1016/j.jmrt.2022.04.106

DO - 10.1016/j.jmrt.2022.04.106

M3 - Article

AN - SCOPUS:85135758484

SN - 2238-7854

VL - 18

SP - 4834

EP - 4845

JO - Journal of Materials Research and Technology

JF - Journal of Materials Research and Technology

ER -

Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: Potential bone tissue engineering and antibacterial properties

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Keywords

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