Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure

Sadiya Bi Shaikh; Ashwini Prabhu; B. Akarsha; Mohamudha Parveen Rahamathulla; Mohemmed Sha; Yashodhar Prabhakar Bhandary

doi:10.1016/j.jiph.2024.01.014

Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure

Sadiya Bi Shaikh, Ashwini Prabhu, B. Akarsha, Mohamudha Parveen Rahamathulla, Mohemmed Sha, Yashodhar Prabhakar Bhandary

Yenepoya University

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Novel coronavirus (SARS nCoV2), belonging to the family coronaviridae, remains a dreadful pathogen affecting the respiratory tract and lungs. COVID-19 declared a global pandemic by WHO, has become a serious cause of concern for clinicians and researchers, who need to understand the significant biology and pathogenicity of this virus to design better treatment modalities. Existing antiretroviral drugs remain partially ineffective in critical subjects with associated co-morbidities. This review provides an insight into the molecular mechanisms by which SARS-CoV2 targets the lungs leading to ARDS in severe cases. This also addresses the possible drug targets and certain anti-inflammatory natural compounds that can be looked upon as promising adjuvant therapeutics for COVID-19.

Original language	English
Pages (from-to)	573-578
Number of pages	6
Journal	Journal of Infection and Public Health
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.jiph.2024.01.014
State	Published - Apr 2024

Keywords

COVID-19
Inflammation
Lung
Natural compounds
SARS-CoV2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiph.2024.01.014

Cite this

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title = "Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure",

abstract = "Novel coronavirus (SARS nCoV2), belonging to the family coronaviridae, remains a dreadful pathogen affecting the respiratory tract and lungs. COVID-19 declared a global pandemic by WHO, has become a serious cause of concern for clinicians and researchers, who need to understand the significant biology and pathogenicity of this virus to design better treatment modalities. Existing antiretroviral drugs remain partially ineffective in critical subjects with associated co-morbidities. This review provides an insight into the molecular mechanisms by which SARS-CoV2 targets the lungs leading to ARDS in severe cases. This also addresses the possible drug targets and certain anti-inflammatory natural compounds that can be looked upon as promising adjuvant therapeutics for COVID-19.",

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T2 - Mechanistic insights and probable candidate molecules for cure

AU - Shaikh, Sadiya Bi

AU - Prabhu, Ashwini

AU - Akarsha, B.

AU - Rahamathulla, Mohamudha Parveen

AU - Sha, Mohemmed

AU - Bhandary, Yashodhar Prabhakar

PY - 2024/4

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AB - Novel coronavirus (SARS nCoV2), belonging to the family coronaviridae, remains a dreadful pathogen affecting the respiratory tract and lungs. COVID-19 declared a global pandemic by WHO, has become a serious cause of concern for clinicians and researchers, who need to understand the significant biology and pathogenicity of this virus to design better treatment modalities. Existing antiretroviral drugs remain partially ineffective in critical subjects with associated co-morbidities. This review provides an insight into the molecular mechanisms by which SARS-CoV2 targets the lungs leading to ARDS in severe cases. This also addresses the possible drug targets and certain anti-inflammatory natural compounds that can be looked upon as promising adjuvant therapeutics for COVID-19.

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KW - Inflammation

KW - Lung

KW - Natural compounds

KW - SARS-CoV2

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Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure

Abstract

Keywords

UN SDGs

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